L-Lactic acid lithium
Based on 12 publication(s) in Google Scholar
L-Lactic acid lithium ((S)-2-Hydroxypropanoic acid lithium) is a buildiing block which can be used as a precursor for the production of the bioplastic polymer poly-lactic acid. L-Lactic acid lithium has antiproliferative activity.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 98.0%
- CAS. Nr.: 27848-80-2
- Formel: C3H5LiO3
- Molecular Weight:96.01
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Speicherung:
Store at room temperature, keep dry and cool.
In solvent -80°C, 1 year , -20°C, 6 months
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Publications Citing Use of MedChemExpress (MCE) L-Lactic acid lithium
More- Adv Sci (Weinh). 2024 Dec 31:e2411943. [Abstract]
- Adv Sci (Weinh). 2024 Mar;11(10):e2304761. [Abstract]
- Small. 2022 Apr;18(13):e2107236. [Abstract]
- Diabetologia. 2024 Jul;67(7):1429-1443. [Abstract]
- Cell Chem Biol. 2026 Feb 19;33(2):213-226.e5. [Abstract]
- Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098. [Abstract]
- Int J Biol Macromol. 2022 Dec 1;222(Pt B):2225-2243. [Abstract]
- Commun Chem. 2025 Dec 9. [Abstract]
- J Autoimmun. 2025 Apr 2:153:103411. [Abstract]
- J Ethnopharmacol. 2025 Jan 31:340:119287. [Abstract]
- Int Immunopharmacol. 2024 Jan 5:126:111265. [Abstract]
- PLoS One. 2025 Sep 18;20(9):e0332825. [Abstract]
Customer Validation & Images
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RT-PCR
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Cell Proliferation/Viability Assay
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Cell Migration/Invasion Assay
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Cell Proliferation/Viability Assay
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WB
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Biologische Aktivität
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Microbial Metabolite |
Human Endogenous Metabolite |
L-Lactic acid (24-48 h) lithium secreted from gastric mucosal cells enhances growth of Helicobacter pylori[1].
L-Lactic acid (48 h) lithium shows antiproliferative activity against human A549 and MRC5 cells, with IC50 of 26.6 μM and 23.93 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 27848-80-2
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Appearance Solid
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Molecular Weight 96.01
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Formel C3H5LiO3
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Color White to off-white
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SMILES
[C@@H](C(O)=O)(C)O.[Li]
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Synonyms
(S)-2-Hydroxypropanoic acid lithium
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Store at room temperature, keep dry and cool
In solvent -80°C 1 year -20°C 6 months
Publications (12)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury. [Abstract]2024 Dec 31:e2411943. PMID: 39737891 -
Adv Sci (Weinh)
Enzymatically Bioactive Nucleus Pulposus Matrix Hydrogel Microspheres for Exogenous Stem Cells Therapy and Endogenous Repair Strategy to Achieve Disc Regeneration. [Abstract]2024 Mar;11(10):e2304761. PMID: 38145353
L-Lactic acid lithium purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Mar;11(10):e2304761. [Abstract]
Evaluation of the viability of BMSCs cultured on microspheres with or without lactate (L-Lactic acid; 6 mM) for 24 h. Fluorescence images of the live/dead assays of BMSCs cultured on microspheres with or without lactate for 24 h.
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Small
Stemness Maintenance and Massproduction of Neural Stem Cells on Poly L-Lactic Acid Nanofibrous Membrane Based on Piezoelectriceffect. [Abstract]2022 Apr;18(13):e2107236. PMID: 35166031 -
Diabetologia
2024 Jul;67(7):1429-1443. PMID: 38676722 -
Cell Chem Biol
2026 Feb 19;33(2):213-226.e5. PMID: 41643668 -
Int J Biol Macromol
Lactate-related genes signature as a novel prognostic landscape in laryngeal squamous cell carcinoma: insights from 156 machine learning algorithms and in vitro validation. [Abstract]2025 Aug 24;323(Pt 1):147098. PMID: 40858160
L-Lactic acid lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098. [Abstract]
Lactate (L-Lactic acid; 24 h) TU668 cells, the expression levels of hub genes were quantified by PCR.
L-Lactic acid lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098. [Abstract]
Lactate (L-Lactic acid; 15 mM; 24, 48, 72 h) cell viability was assessed using the CCK-8 assay in TU686 cells.
L-Lactic acid lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2025 Aug 24;323(Pt 1):147098. [Abstract]
Lactate (L-Lactic acid; 15 mM; 0, 48 h), cell migration capacity was evaluated via a scratch wound healing assay in TU686 cells.
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Int J Biol Macromol
HIF1α lactylation enhances KIAA1199 transcription to promote angiogenesis and vasculogenic mimicry in prostate cancer. [Abstract]2022 Dec 1;222(Pt B):2225-2243. PMID: 36209908
L-Lactic acid lithium purchased from MedChemExpress. Usage Cited in: Int J Biol Macromol. 2022 Dec 1;222(Pt B):2225-2243. [Abstract]
Assessed by WB, extracellular lactate (L-Lactic acid) treatment (10 mM, 72 h) significantly increased VE-cadherin and p-EphA2 (Ser897) expressions, which could be reversed by MCT1 silencing PC-3 cells.
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Commun Chem
Stepped collisional energy improves protein acylation identification by eliminating positional bias of cyclic immonium ions. [Abstract]2025 Dec 9. PMID: 41366033 -
J Autoimmun
Neutrophil extracellular traps induce trophoblasts pyroptosis via enhancing NLRP3 lactylation in SLE pregnancies. [Abstract]2025 Apr 2:153:103411. PMID: 40179478 -
J Ethnopharmacol
Icariin maintaining TMEM119-positive microglial population improves hippocampus-associated memory in senescent mice in relation to R-3-hydroxybutyric acid metabolism. [Abstract]2025 Jan 31:340:119287. PMID: 39736348 -
Int Immunopharmacol
Identifying the critical oncogenic mechanism of LDHA based on a prognostic model of T-cell synthetic drivers. [Abstract]2024 Jan 5:126:111265. PMID: 38000233 -
PLoS One
2025 Sep 18;20(9):e0332825. PMID: 40966256
Lösungsmittel & Löslichkeit
H2O : 125 mg/mL (1301.95 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. 1. Takahashi T, et al. L-lactic acid secreted from gastric mucosal cells enhances growth of Helicobacter pylori. Helicobacter. 2007 Oct;12(5):532-40. [Content Brief]
[2]. 2. Recio R, et al. Design, synthesis and biological studies of a library of NK1-Receptor Ligands Based on a 5-arylthiosubstituted 2-amino-4,6-diaryl-3-cyano-4H-pyran core: Switch from antagonist to agonist effect by chemical modification. Eur J Med Chem. 2017 Sep 29;138:644-660. [Content Brief]
[3]. 3. Zhang G, et al. L-lactic acid's improvement of swimming endurance in mice. Int J Sport Nutr Exerc Metab. 2009 Dec;19(6):673-84. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 10.4156 mL | 52.0779 mL | 104.1558 mL | 260.3895 mL |
| 5 mM | 2.0831 mL | 10.4156 mL | 20.8312 mL | 52.0779 mL | |
| 10 mM | 1.0416 mL | 5.2078 mL | 10.4156 mL | 26.0390 mL | |
| 15 mM | 0.6944 mL | 3.4719 mL | 6.9437 mL | 17.3593 mL | |
| 20 mM | 0.5208 mL | 2.6039 mL | 5.2078 mL | 13.0195 mL | |
| 25 mM | 0.4166 mL | 2.0831 mL | 4.1662 mL | 10.4156 mL | |
| 30 mM | 0.3472 mL | 1.7359 mL | 3.4719 mL | 8.6797 mL | |
| 40 mM | 0.2604 mL | 1.3019 mL | 2.6039 mL | 6.5097 mL | |
| 50 mM | 0.2083 mL | 1.0416 mL | 2.0831 mL | 5.2078 mL | |
| 60 mM | 0.1736 mL | 0.8680 mL | 1.7359 mL | 4.3398 mL | |
| 80 mM | 0.1302 mL | 0.6510 mL | 1.3019 mL | 3.2549 mL | |
| 100 mM | 0.1042 mL | 0.5208 mL | 1.0416 mL | 2.6039 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
L-Lactic acid lithium Related Classifications
HY-D0884 Related Classifications
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