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Art. -Nr.: HY-182436

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MINA53-IN-1

Name: MINA53-IN-1
Brand: MedChemExpress
SKU: HY-182436
Price: 105.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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MINA53-IN-1 is a selective MINA53 inhibitor with an IC₅₀ of 1.5 μM. MINA53-IN-1 induces DNA damage, cell cycle arrest and apoptosis in tumor cells. MINA53-IN-1 can be used for cancer research.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.55%
CAS. Nr.: 2863676-85-9
Formel: C₁₄H₁₄N₂O₃S
Molecular Weight:290.34

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

MINA53-IN-1 Chemical Structure

CAS. Nr.: 2863676-85-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	14 μM Compound: 10	Antiproliferative activity against human HL-60 cells incubated for 48 hrs by WST-1 assay Antiproliferative activity against human HL-60 cells incubated for 48 hrs by WST-1 assay	[PMID: 34843649]

In Vitro

MINA53-IN-1 (compound 10) inhibits the proliferation of HL-60 acute promyelocytic leukemia cells after 48 h, with an IC₅₀ of 14 μM^[1].
MINA53-IN-1 (10-100 μM; 72-120 h) reduces the viability of U-87MG glioblastoma cells, MNK-45 gastric cancer cells and HeLa cervical cancer cells in a dose- and time-dependent manner^[1].
MINA53-IN-1 (10-20 μM; 24 h) induces DNA damage, G₂/M cell cycle arrest and apoptosis in U-87MG cells, and acts synergistically with Doxorubicin (HY-15142A) to enhance apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

U-87MG malignant glioma cells, MNK-45 gastric carcinoma cells, HeLa cervical carcinoma cells
Concentration:

10, 50, 100 μM
Incubation Time:

72, 96, 120 h
Result:

Reduced cell viability in a dose- and time-dependent manner.

Chemical Information

CAS. Nr. 2863676-85-9
Appearance Solid
Molecular Weight 290.34
Formel C₁₄H₁₄N₂O₃S
SMILES

O=C(C1=CN=C(NC1=O)SCCCC2=CC=CC=C2)O
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nowak RP, et al. First-in-Class Inhibitors of the Ribosomal Oxygenase MINA53. J Med Chem. 2021;64(23):17031-17050. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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