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Art. -Nr.: HY-101115

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PI3K-IN-6

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

PI3K-IN-6 (compound 20a) is an oral active and highly selective phosphoinositide 3-kinase (PI3K) β/δ inhibitor, with IC₅₀ values of 7.8 nM/5.3 nM for PI3K β/δ, respectively. PI3K-IN-6 (compound 20a) has potential top treat phosphatase and tensin homolog (PTEN) feficient tumors.

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CAS. Nr.: 1842380-77-1
Formel: C₁₇H₁₄Cl₂FN₉O
Molecular Weight:450.26

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

PI3K-IN-6 Chemical Structure

CAS. Nr.: 1842380-77-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

PI3Kβ

7.8 nM (IC₅₀)

PI3Kδ

5.3 nM (IC₅₀)

PI3Kα

850 nM (IC₅₀)

Alle PI3K Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A498	GI₅₀	80 nM Compound: 20a	Growth inhibition of human A498 cells harboring PI3Kbeta mutant after 72 hrs by Celltiter-Glo reagent based assay Growth inhibition of human A498 cells harboring PI3Kbeta mutant after 72 hrs by Celltiter-Glo reagent based assay	[PMID: 28106991]
LNCaP	GI₅₀	38 nM Compound: 20a	Growth inhibition of PTEN-deficient human LNCAP cells after 72 hrs by Celltiter-Glo reagent based assay Growth inhibition of PTEN-deficient human LNCAP cells after 72 hrs by Celltiter-Glo reagent based assay	[PMID: 28106991]
MDA-MB-415	GI₅₀	12 nM Compound: 20a	Growth inhibition of PTEN-deficient human MDA-MB-415 cells after 72 hrs by Celltiter-Glo reagent based assay Growth inhibition of PTEN-deficient human MDA-MB-415 cells after 72 hrs by Celltiter-Glo reagent based assay	[PMID: 28106991]
PC-3	GI₅₀	120 nM Compound: 20a	Growth inhibition of PTEN-deficient human PC3 cells after 72 hrs by Celltiter-Glo reagent based assay Growth inhibition of PTEN-deficient human PC3 cells after 72 hrs by Celltiter-Glo reagent based assay	[PMID: 28106991]
ZR-75-1	GI₅₀	2 nM Compound: 20a	Growth inhibition of PTEN-deficient human ZR-75-1 cells after 72 hrs by Celltiter-Glo reagent based assay Growth inhibition of PTEN-deficient human ZR-75-1 cells after 72 hrs by Celltiter-Glo reagent based assay	[PMID: 28106991]

Chemical Information

CAS. Nr. 1842380-77-1
Molecular Weight 450.26
Formel C₁₇H₁₄Cl₂FN₉O
SMILES

FC1=CC(Cl)=C(N=C([C@@H](NC2=C(Cl)C(N)=NC(N)=N2)C)N(C3=NNC=C3)C4=O)C4=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Journal Impact Factor

Neuropsychiatr Dis Treat

The Impact of Esketamine on Depression: Targeting Oxidative Stress and Neuronal Apoptosis Through BDNF/TrkB/PI3K/AKT Pathway Activation. [Abstract]

2025 Aug 25:21:1783-1793. PMID: 40893928

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Perreault S, et al. Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856. J Med Che [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

PI3K-IN-6

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Publications (1)
Reinheit & Dokumentation
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PI3K-IN-6

Publications Citing Use of MedChemExpress (MCE) PI3K-IN-6

Alle PI3K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

PI3K-IN-6 Related Classifications

HY-101115 Related Classifications