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Tulisokibart

(Synonyms: PRA023; MK-7240)
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Based on 1 publication(s) in Google Scholar

Tulisokibart (PRA023) is a humanized IgG1-κ monoclonal antibody. Tulisokibart targets to TNFSF15/TL1A. Tulisokibart can be used to study a variety of inflammatory/fibrotic diseases, such as Crohn's Disease (CD) and ulcerative colitis.

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  • Reinheit: 98.69%
  • CAS. Nr.: 2648504-55-4
  • Molecular Weight:143.96 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Tulisokibart
  • Experimental Validation Results for Tulisokibart
  • Experimental Validation Results for Tulisokibart
  • Experimental Validation Results for Tulisokibart
  • Tulisokibart Chemical Structure
    Tulisokibart Chemical Structure
CAS. Nr.: 2648504-55-4
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609-228-6898
[email protected] [email protected]
Finden Sie Ihren Händler vor Ort Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometric analysis of 1×106 MCF-7 cells labelling TL1A (red) with Tulisokibart (HY-P990007). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Immobilized TL1A/TNFSF15 Protein, Human can bind Tulisokibart. The EC50 for this effect is 15.31 ng/mL.

  • 1/16

    Loaded Tulisokibart on AHC2 biosensor, can bind TL1A/TNFSF15 Protein, Human (HY-P71913) with an affinity constant of 3.693E-10 M as determined in BLI assay.

  • Tulisokibart Chemical Structure
    1/16
  • Tulisokibart
  • Flow cytometric analysis of 1×106 MCF-7 cells labelling TL1A (red) with Tulisokibart (HY-P990007). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 kappa Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).
  • Immobilized TL1A/TNFSF15 Protein, Human can bind Tulisokibart. The EC50 for this effect is 15.31 ng/mL.
  • Loaded Tulisokibart on AHC2 biosensor, can bind TL1A/TNFSF15 Protein, Human (HY-P71913) with an affinity constant of 3.693E-10 M as determined in BLI assay.