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Belimumab

(Synonyms: LymphoStat B)
5 Cited Publications
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Based on 5 publication(s) in Google Scholar

Belimumab (LymphoStat B) is a humanized IgG1λ monoclonal antibody against B-lymphocyte stimulator (BLyS) protein. Belimumab antagonizes BLyS activity in autoimmune diseases and B-lymphocyte malignancies. Belimumab can be used for systemic lupus erythematosus (SLE) research. The component ratio of this product is Active ingredient: Excipients = 1:1.0-1:1.2.

For research use only. We do not sell to patients.

  • Purity: 99.40%
  • CAS No.: 356547-88-1
  • Molecular Weight:144.54 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Belimumab
  • Experimental Validation Results for Belimumab
  • Experimental Validation Results for Belimumab
  • Experimental Validation Results for Belimumab
  • Belimumab Chemical Structure
    Belimumab Chemical Structure
CAS No.: 356547-88-1
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Belimumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 lambda

  • 1/16

    Immobilized BAFF/TNFSF13B Protein, Human (CHO, HY-P7003) can bind Belimumab. The EC50 for this effect is 12 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 THP-1 cells with Belimumab (HY-P9952, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 Isotype Control (HY-P990096, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Belimumab purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Aug 1. [Abstract]

    Customer Validation
     Bone marrow mononuclear cells (BMMCs) from acquired resistant PCM patients were used in Dara-induced ADCC assays. CD138-positive plasma cells were quantified by flow cytometry. BMMCs were treated with Dara (5 or 10 μg/mL) ± inhibitors (Belimumab [BAFF], 4-IPP [MIF], and MYCi975 [MYC]) for 24 h, then co-cultured with NK-cells at an effector:target (E:T) ratio = 1:1 for 12 h. The amount of released LDH was determined using a cytotoxicity assay kit to calculate the % of lysed cells.

  • Belimumab Chemical Structure
    1/16
  • Belimumab
  • Immobilized BAFF/TNFSF13B Protein, Human (CHO, HY-P7003) can bind Belimumab. The EC50 for this effect is 12 ng/mL.
  • Flow cytometric analysis of 1.5×106 THP-1 cells with Belimumab (HY-P9952, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 lambda2 Isotype Control (HY-P990096, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).