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Fulvine

Fulvine is a pyrrolizidine alkaloid isolated from the seeds of Crotalaria fulva. Fulvine is hepatotoxic and can be used to induce hypertensive pulmonary vascular disease in vivo.

For research use only. We do not sell to patients.

CAS No.: 6029-87-4
Formula: C₁₆H₂₃NO₅
Molecular Weight:309.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (283 KB)

Fulvine Chemical Structure

CAS No.: 6029-87-4

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Biological Activity
- Description
- Induced Disease Models
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

Fulvine is a pyrrolizidine alkaloid isolated from the seeds of Crotalaria fulva. Fulvine is hepatotoxic and can be used to induce hypertensive pulmonary vascular disease in vivo^[1].

Induced Disease Models

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Fulvine can be used in animal modeling to create respiratory disease models^[1]^[2].

Induction of respiratory and liver disease^[1]^[2].

Background

Fulvine on reaching the liver is metabolically converted into a cellular toxin. Some of this toxin is retained in the hepatic cells, and produces necrosis and other cellular changes. Some of the toxin escapes to damage the vascular endothelium in the hepatic veins. This may take the form of endothelial proliferation with the later changes characteristic of veno-occlusion. Carried further, the escaping toxic metabolites reach the pulmonary tissues to produce vascular changes with increased capillary permeability and progressive oedema and cellular changes in the lungs, including the development of the big cells and the accumulation of mast cells^[2].

Specific Modeling Methods

Rat: White SPF and conventional• Male and Female• weighing 50-65 g and 45-60 g^[1]
Administration: 30-45 mg/kg• neutralised aqueous solution by stomach tube• a single dose^[1]
Rat: Male and Female• weighing 40-80 g^[2]
Administration: 50 mg/kg• given by stomach tube• a single dose^[2]

Note

(1)SPF rats and conventional rats were kept separately. All were weighed at least weekly. Rats that died or were killed with coal-gas when ill were examined post mortem. Lungs, liver and other tissues from representative animals were fixed in Hefly’s fluid; paraffin sections were stained with haematoxylin and eosin^[1]
.
Crystalline Fulvine was dissolved in dilute hydrochloric acid, neutralised and diluted to give a 1% solution^[2]
.

Modeling Indicators

Pathology change: The lungs were congested or oedematous and did not collapse when the chest was opened, showing petechiae or small dark red patches. Large often bloodstained, effusions were present in many rats. The liver appeared enlarged, dark red with a brownish tint, slightly granular and rubbery. The heart seemed enlarged; some rats had gastro-intestinal haemorrhage and prominent red lymph-glands. Varying degrees of ascites were present, and the ventral skin was often oedematous^[1]
.
Behavioral observation: Fulvine induced some developed difficulty in breathing and slowing or cessation of growth in rats^[1]
.
Histological analysis: Fulvine induced moderate ascites, well marked fibrous thickening of the central vein walls, endothelial proliferation and some perivascular centrilobular fibrosis with possibly partial venous occlusion^[2]
.

Correlated Product(s): Monocrotaline (HY-N0750); Crispatine

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6029-87-4
Molecular Weight 309.36
Formula C₁₆H₂₃NO₅
SMILES

O=C(O[C@]1([H])CCN2[C@]1([H])C(CO3)=CC2)[C@H](C)[C@@](C)(O)[C@H](C)C3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (283 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schoental R. Rat lung lesions due to Fulvine. J Pathol Bacteriol. 1966 Apr;91(2):629-31. [Content Brief]

[2]. BARNES JM, et al. LESIONS IN THE LUNGS AND LIVERS OF RATS POISONED WITH THE PYRROLIZIDINE ALKALOID Fulvine AND ITS N-OXIDE. J Pathol Bacteriol. 1964 Oct;88:521-31. [Content Brief]

[3]. J M Kay, et al.Fulvine and the pulmonary circulation. Thorax [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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