Cat. No.: HY-N0189

Aloe emodin

(Synonyms: Rhabarberone; 3-Hydroxymethylchrysazine)

3 Cited Publications

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Based on 3 publication(s) in Google Scholar

Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis. Aloe emodin also exhibits antiviral activity that against influenza A virus.

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Pureté: 98.32%
CAS No.: 481-72-1
Formule: C₁₅H₁₀O₅
Masse moléculaire:270.24

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Aloe emodin Chemical Structure

CAS No.: 481-72-1

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Aloe emodin (Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities. aloe-emodin can bind with mTORC2 and inhibit its kinase activity. Aloe emodin exerts antiproliferation effects and induces cellular apoptosis^[1]. Aloe emodin also exhibits antiviral activity that against influenza A virus^[2].

IC₅₀ & Target^[1]

mTORC2

Voir tous les produits spécifiques à Isoform mTOR :

Cellular Effect

Cell Line	Type	Value	Description	References
A2780	IC₅₀	26 μM Compound: 2	Cytotoxicity against human A2780 cells Cytotoxicity against human A2780 cells	[PMID: 24326280]
B16-F10	IC₅₀	3.12 μM Compound: 1	Anticancer activity against mouse B16-F10 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Anticancer activity against mouse B16-F10 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34124677]
HCT-116	IC₅₀	8.7 μM Compound: 4	Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay Cytotoxicity against MDR1 Pgp under-expressing human HCT116 cells after 24 hrs by MTT assay	[PMID: 17949858]
HEK293	IC₅₀	1 μM Compound: 1	Cytotoxicity against human HEK293 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34124677]
HepG2	IC₅₀	10 μM Compound: 4	Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay Cytotoxicity against MDR1 Pgp overexpressing human HepG2 cells after 24 hrs by MTT assay	[PMID: 17949858]
HepG2	IC₅₀	6.13 μM Compound: 1	Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34124677]
HepG2 2.2.15	IC₅₀	300 μg/mL Compound: 54	Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV DNA production Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV DNA production	[PMID: 24549242]
HepG2 2.2.15	IC₅₀	300 μg/mL Compound: 54	Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion	[PMID: 24549242]
HepG2 2.2.15	IC₅₀	300 μg/mL Compound: 54	Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion	[PMID: 24549242]
Huh-7	CC₅₀	>50 μM Compound: 25	Cytotoxicity against human Huh7.5.1 cells by MTT assay Cytotoxicity against human Huh7.5.1 cells by MTT assay	[PMID: 22445328]
Huh-7	EC₅₀	20.8 μM Compound: 25	Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay Antiviral activity against HCV JFH-1 J399EM infected in Human Huh7.5.1 cells assessed as suppression of viral replication after 72 hrs by EGFP assay	[PMID: 22445328]
MCF7	IC₅₀	>20 μM Compound: AE	Cytotoxicity against human MCF7 cells after 24 hrs by XTT assay Cytotoxicity against human MCF7 cells after 24 hrs by XTT assay	[PMID: 24900344]
MCF7	IC₅₀	4.14 μM Compound: 1	Anticancer activity against human MCF-7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Anticancer activity against human MCF-7 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34124677]
MDA-MB-231	IC₅₀	12.24 μM Compound: 1	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay	[PMID: 34124677]
MOLT-4	IC₅₀	>20 μM Compound: AE	Cytotoxicity against human MOLT4 cells after 24 hrs by XTT assay Cytotoxicity against human MOLT4 cells after 24 hrs by XTT assay	[PMID: 24900344]
OVCAR-3	IC₅₀	>20 μM Compound: AE	Cytotoxicity against human OVCAR3 cells after 24 hrs by XTT assay Cytotoxicity against human OVCAR3 cells after 24 hrs by XTT assay	[PMID: 24900344]
SK-OV-3	IC₅₀	>20 μM Compound: AE	Cytotoxicity against human SKOV3 cells after 24 hrs by XTT assay Cytotoxicity against human SKOV3 cells after 24 hrs by XTT assay	[PMID: 24900344]

In Vitro

Aloe emodin (0-15 μM; 24-96 h) inhibits PC3 cell proliferation in a dose-dependent manner^[1].
Aloe emodin (0-15 μM; 24 h) inhibits the activation of mTORC2 downstream substrates, Akt and PKCα. Aloe emodin could bind with mTORC2 in cells and inhibit its kinase activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

PC3 cells
Concentration:

0 μM, 2.5 μM, 5 μM, 10 μM or 15 μM
Incubation Time:

24 h, 48 h, 72 h or 96 h
Result:

Suppressed proliferation and anchorage-independent growth of PC3 cells.

Western Blot Analysis^[1]

Cell Line:

PC3 cells
Concentration:

0 μM, 2.5 μM, 5 μM, 10 μM or 15 μM
Incubation Time:

24 h
Result:

Inhibited the activation of the downstream substrates of mTORC2, Akt and PKCα.

In Vivo

Aloe emodin (10-50 mg/kg) suppresses tumor growth by inhibiting mTOR complex2 activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Athymic nude mice (BALB/c nude mouse, 6 weeks old)^[1]
Dosage:

10 mg/kg, 50 mg/kg (20% PEG400 in autoclaved PBS)
Administration:

Intraperitoneal injection, five times per week; for 28 days
Result:

Exhibited tumor suppression effects in vivo in an athymic nude mouse model.

Chemical Information

CAS No. 481-72-1
Appearance Solid
Masse moléculaire 270.24
Formule C₁₅H₁₀O₅
Color Brown to orange
SMILES

O=C1C2=C(C=CC=C2O)C(C3=CC(CO)=CC(O)=C13)=O
Synonyms

Rhabarberone; 3-Hydroxymethylchrysazine
Structure Classification
- Quinones
- Anthraquinones
- Phenols
- Polyphenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

All In Vivo Efficacy StudyHistological Imaging/StainingELISA

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Journal Impact Factor

Biomed Res Int

Anti-influenza A Virus Effects and Mechanisms of Emodin and Its Analogs via Regulating PPAR α/ γ-AMPK-SIRT1 Pathway and Fatty Acid Metabolism. [Abstract]

2021 Sep 9;2021:9066938. PMID: 34540999
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
Heliyon

Aloe-emodin alleviates inflammatory bowel disease in mice by modulating intestinal microbiome homeostasis via the IL-4/IL-13 axis. [Abstract]

2024 Jul 22;10(15):e34932. PMID: 39157379

Aloe emodin purchased from MedChemExpress. Usage Cited in: Heliyon. 2024 Jul 22;10(15):e34932. [Abstract]

Changes in body weights of mice were monitored following treatment with different doses of AE (Aloe emodin) in a mouse model of colitis induced by DSS.

Aloe emodin purchased from MedChemExpress. Usage Cited in: Heliyon. 2024 Jul 22;10(15):e34932. [Abstract]

Aloe emodin (5,10,50 mg/mL). H&E staining of colon tissue sections. Histological evaluation of H&E-stained colon tissue sections to assess tissue damage and inflammation.

Aloe emodin purchased from MedChemExpress. Usage Cited in: Heliyon. 2024 Jul 22;10(15):e34932. [Abstract]

Aloe emodin (5, 10, 50 mg/kg). Serum levels of inflammatory cytokines IL-17 and TNF-α were detected by ELISA.

Solvant et solubilité

In Vitro:

DMSO : ≥ 20.83 mg/mL (77.08 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7004 mL

18.5021 mL

37.0041 mL

5 mM

0.7401 mL

3.7004 mL

7.4008 mL

10 mM

0.3700 mL

1.8502 mL

3.7004 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.08 mg/mL (7.70 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.08 mg/mL (7.70 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (277 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Liu K, et al. Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2. Carcinogenesis. 2012 Jul;33(7):1406-11. [Content Brief]

[2]. Li SW, et al. Antiviral activity of aloe-emodin against influenza A virus via galectin-3 up-regulation. Eur J Pharmacol. 2014 Sep 5;738:125-32. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.7004 mL	18.5021 mL	37.0041 mL	92.5104 mL
	5 mM	0.7401 mL	3.7004 mL	7.4008 mL	18.5021 mL
	10 mM	0.3700 mL	1.8502 mL	3.7004 mL	9.2510 mL
	15 mM	0.2467 mL	1.2335 mL	2.4669 mL	6.1674 mL
	20 mM	0.1850 mL	0.9251 mL	1.8502 mL	4.6255 mL
	25 mM	0.1480 mL	0.7401 mL	1.4802 mL	3.7004 mL
	30 mM	0.1233 mL	0.6167 mL	1.2335 mL	3.0837 mL
	40 mM	0.0925 mL	0.4626 mL	0.9251 mL	2.3128 mL
	50 mM	0.0740 mL	0.3700 mL	0.7401 mL	1.8502 mL
	60 mM	0.0617 mL	0.3084 mL	0.6167 mL	1.5418 mL

Keywords

Aloe emodin

3 Cited Publications

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Aloe emodin

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Publications Citing Use of MedChemExpress (MCE) Aloe emodin

Voir tous les produits spécifiques à Isoform mTOR

Activité biologique

Chemical Information

Publications (3)

Solvant et solubilité

Pureté et documentation