Cat. No.: HY-Y0366

Lauric acid

7 Cited Publications

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Based on 7 publication(s) in Google Scholar

Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively.

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Pureté: 99.93%
CAS No.: 143-07-7
Formule: C₁₂H₂₄O₂
Masse moléculaire:200.32

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lauric acid Chemical Structure

CAS No.: 143-07-7

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Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (7)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Lauric acid is a middle chain-free fatty acid with strong bactericidal properties. The EC₅₀s for P. acnes, S.aureus, S. epidermidis, are 2, 6, 4 μg/mL, respectively^[1].

IC₅₀ & Target

Human Endogenous Metabolite

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	3.49 μM Compound: 18	Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	[PMID: 31721581]
CHO	EC₅₀	8.87 μM Compound: 18	Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 m Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 m	[PMID: 31721581]

In Vitro

Lauric acid (0.06-125 μg/ml, 24-72 h) has much stronger antimicrobial activity in P. acnes, S.aureus, and S. epidermidis^[1].
Lauric acid (5-50 μM, 24 h) increases glucose uptake and decreases GLUT-1 expression and cellular H2O2 production in insulin-resistant macrophages^[2].
Lauric acid (5-50 μM, 24 h) enhances mitochondrial content and mitochondrial biogenesis in the insulin-resistant macrophages^[2].
Lauric acid (5-50 μM, 24 h) promotes the gene expressions (PPAR-γ, TFAM and PGC-1α) in THP-1 macrophages^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Lauric acid (0.1 μg/μL, i.h., once time) can effectively relieve P. acnes-induced inflammation without detrimental effects on skin cells in mice injected with P. acnes^[1].
Lauric acid (1-10 mg/kg, i.v., once time) reduces blood pressure and heart rate in WKY and SHR rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 143-07-7
Appearance Solid
Masse moléculaire 200.32
Formule C₁₂H₂₄O₂
Color White to off-white
SMILES

CCCCCCCCCCCC(O)=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (7)

All Cell Proliferation/Viability AssayCell Imaging/StainingFlow CytometryWB

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Food Sci Hum Wellness

2026 Mar 3.
Nutrients

Medium-Chain Fatty Acids Selectively Sensitize Cancer Cells to Ferroptosis by Inducing CD36 and ACSL4. [Abstract]

2025 Feb 25;17(5):794. PMID: 40077664

Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794. [Abstract]

U937 human leukemia cells were treated with Lauric acid (LA-m), RSL3 or their combination in the absence or presence of ferroptosis inhibitor Lip-1 for 24 h, and their viability was assayed using CCK8.

Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794. [Abstract]

RINm5F rat insulinoma cells were exposed to Lauric acid (LA-m) and RSL3 alone or their combination in the absence or presence of ferroptosis inhibitor Lip-1 for 24 h, and the changes of cell viability were measured through crystal violet staining.

Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794. [Abstract]

U937 human leukemia cells were treated with Lauric acid (LA-m), LA-l or their combination for 24 h, and cell viability was assessed by CCK8.

Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794. [Abstract]

RINm5F rat insulinoma cells were treated with Lauric acid (LA-m), LA-l or their combination for 24 h, and cell viability was determined by crystal violet staining.

Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794. [Abstract]

After the treatment, the levels of intracellular LPO were quantified using flow cytometry after staining with Liperfluo in U937 human leukemia cells. "+" means: combination of Lauric acid and LA-l.

Lauric acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794. [Abstract]

CD36 and ACSL4 protein levels in A549 lung cancer cells with treatment with Lauric acid for 12 h.
Int Immunopharmacol

Minimolide F alleviates inflammatory diseases by specifically targeting STING and blocking IRF3 recruitment. [Abstract]

2026 May 1:176:116468. PMID: 41819671
Mol Neurobiol

Brain Immune Cell Infiltration and Serum Metabolomic Characteristics Reveal that Lauric Acid Promotes Immune Cell Infiltration in Brain and Streptococcus suis Meningitis in Mice. [Abstract]

2024 Nov;61(11):9302-9319. PMID: 38625620
Biochem Biophys Res Commun

Medium-chain fatty acids activate fructose metabolism via up-regulating GLUT5-KHK axis. [Abstract]

2026 Mar 12:804:153358. PMID: 41619507
Res Sq

2025 Nov 18.

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (499.20 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

0.1 M NaOH : 10 mg/mL (49.92 mM; ultrasonic and warming and adjust pH to 11 with NaOH and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.9920 mL

24.9601 mL

49.9201 mL

5 mM

0.9984 mL

4.9920 mL

9.9840 mL

10 mM

0.4992 mL

2.4960 mL

4.9920 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (10.38 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (10.38 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
SDS (476 KB)
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- Portuguese - PT (476 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Nakatsuji T, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009 Oct;129(10):2480-8. [Content Brief]

[2]. Tham YY, et al. Lauric acid alleviates insulin resistance by improving mitochondrial biogenesis in THP-1 macrophages. Mol Biol Rep. 2020 Dec;47(12):9595-9607. [Content Brief]

[3]. Alves NF, et al. Acute Treatment with Lauric Acid Reduces Blood Pressure and Oxidative Stress in Spontaneously Hypertensive Rats. Basic Clin Pharmacol Toxicol. 2017 Apr;120(4):348-353. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
0.1 M NaOH / DMSO	1 mM	4.9920 mL	24.9601 mL	49.9201 mL	124.8003 mL
	5 mM	0.9984 mL	4.9920 mL	9.9840 mL	24.9601 mL
	10 mM	0.4992 mL	2.4960 mL	4.9920 mL	12.4800 mL
	15 mM	0.3328 mL	1.6640 mL	3.3280 mL	8.3200 mL
	20 mM	0.2496 mL	1.2480 mL	2.4960 mL	6.2400 mL
	25 mM	0.1997 mL	0.9984 mL	1.9968 mL	4.9920 mL
	30 mM	0.1664 mL	0.8320 mL	1.6640 mL	4.1600 mL
	40 mM	0.1248 mL	0.6240 mL	1.2480 mL	3.1200 mL
DMSO	50 mM	0.0998 mL	0.4992 mL	0.9984 mL	2.4960 mL
	60 mM	0.0832 mL	0.4160 mL	0.8320 mL	2.0800 mL
	80 mM	0.0624 mL	0.3120 mL	0.6240 mL	1.5600 mL
	100 mM	0.0499 mL	0.2496 mL	0.4992 mL	1.2480 mL

Keywords

Lauric acid

7 Cited Publications

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Lauric acid

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Publications Citing Use of MedChemExpress (MCE) Lauric acid

Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Activité biologique

Chemical Information

Publications (7)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Lauric acid Related Classifications

HY-Y0366 Related Classifications