Cat. No.: HY-41417

Octanoic acid

(Synonyms: Caprylic acid)

3 Cited Publications

Customer Review

Based on 3 publication(s) in Google Scholar

Octanoic acid (Caprylic acid) is an oily liquid with a slightly unpleasant rancid taste and used commercially in the production of esters used in perfumery and also in the manufacture of dyes. Octanoic acid is also a tremor-suppressing agent.

For research use only. We do not sell to patients.

Purity: 99.68%
CAS No.: 124-07-2
Formula: C₈H₁₆O₂
Molecular Weight:144.21

Storage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

Octanoic acid Chemical Structure

CAS No.: 124-07-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (3)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target

Human Endogenous Metabolite

All Endogenous Metabolite Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	>100 μM Compound: 16	Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as beta-arrestin 2 recruitment measured after 90 mins by beta-galactosidase based PathHunter assay	[PMID: 31721581]
CHO	EC₅₀	>100 μM Compound: 16	Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 m Agonist activity at recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as inhibition of forskolin-stimulated [3H]cAMP accumulation preincubated for 5 mins followed by forskolin stimulation and measured after 15 m	[PMID: 31721581]

In Vitro

Octanoic acid (0-0.5 mM, 0.5 h) potentiates glucose-stimulated insulin secretion (GSIS) in MIN6 cells, via Olfr15 though the PLC-IP3 pathway^[4].
Octanoic acid (0-10 mM, 48 h) induces neurite outgrowth in PC12 cells, and activates p38 MAPK and ERK pathways^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[5]

Cell Line:

PC12 cells
Concentration:

3 mM
Incubation Time:

0-24 h
Result:

Increased p38 MAPK, ERK, and JNK level.

In Vivo

Octanoic acid (1500 mg/kg, i.p.) inhibits harmaline tremor in mouse model of essential tremor^[1].
Octanoic acid (150 mg/kg, oral gavage) shows protective effects in the mouse model of PD induced by MPTP (HY-15608)^[2].
Octanoic acid (1.3 mg, p.o.) promotes branched-chain amino acid (BCAA) catabolism in rats by activating BCKDC via decreasing the bound form of BCKDH kinase (BDK)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 124-07-2
Appearance Solid-Liquid Mixture
Molecular Weight 144.21
Formula C₈H₁₆O₂
Color Colorless to light yellow
SMILES

CCCCCCCC(O)=O
Synonyms

Caprylic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Publications (3)

All WBCell Proliferation/Viability Assay

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Journal Impact Factor

Mol Cell

CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity. [Abstract]

2023 Dec 7;83(23):4370-4385.e9. PMID: 38016475
Nutrients

Medium-Chain Fatty Acids Selectively Sensitize Cancer Cells to Ferroptosis by Inducing CD36 and ACSL4. [Abstract]

2025 Feb 25;17(5):794. PMID: 40077664

Octanoic acid purchased from MedChemExpress. Usage Cited in: Nutrients. 2025 Feb 25;17(5):794. [Abstract]

Compared with the untreated group, Octanoic acid (OA-m) (200 μM; 24 h), DA-m or LA-l alone did not significantly affect cell viability. However, the combination of OA-m with LA-l decreased U937 cell viability to 70.7%.
Biochem Biophys Res Commun

Medium-chain fatty acids activate fructose metabolism via up-regulating GLUT5-KHK axis. [Abstract]

2026 Mar 12:804:153358. PMID: 41619507

Octanoic acid purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2026 Mar 12:804:153358. [Abstract]

Effects of Octanoic acid (OA) (100, 150, 200 μM; 24 h) on the expression of the fructose transporter GLUT5 and ketohexokinase (KHK) in IEC-18 intestinal epithelial cells.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (693.43 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

6.9343 mL

34.6717 mL

69.3433 mL

5 mM

1.3869 mL

6.9343 mL

13.8687 mL

10 mM

0.6934 mL

3.4672 mL

6.9343 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (14.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (14.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (14.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Portuguese - PT (476 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Nahab FB, et al. Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor. Neurotherapeutics. 2012 Jul;9(3):635-8. [Content Brief]

[2]. Joniec-Maciejak I, et al. Octanoic acid prevents reduction of striatal dopamine in the MPTP mouse model of Parkinson's disease. Pharmacol Rep. 2018 Oct;70(5):988-992. [Content Brief]

[3]. Kadota Y, et al. Octanoic acid promotes branched-chain amino acid catabolisms via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats. Metabolism. 2015 Sep;64(9):1157-64. [Content Brief]

[4]. Leem J, et al. Octanoic acid potentiates glucose-stimulated insulin secretion and expression of glucokinase through the olfactory receptor in pancreatic β-cells. Biochem Biophys Res Commun. 2018 Sep 3;503(1):278-284. [Content Brief]

[5]. Kamata Y, et al. Induction of neurite outgrowth in PC12 cells by the medium-chain fatty acid octanoic acid. Neuroscience. 2007 May 25;146(3):1073-81. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	6.9343 mL	34.6717 mL	69.3433 mL	173.3583 mL
	5 mM	1.3869 mL	6.9343 mL	13.8687 mL	34.6717 mL
	10 mM	0.6934 mL	3.4672 mL	6.9343 mL	17.3358 mL
	15 mM	0.4623 mL	2.3114 mL	4.6229 mL	11.5572 mL
	20 mM	0.3467 mL	1.7336 mL	3.4672 mL	8.6679 mL
	25 mM	0.2774 mL	1.3869 mL	2.7737 mL	6.9343 mL
	30 mM	0.2311 mL	1.1557 mL	2.3114 mL	5.7786 mL
	40 mM	0.1734 mL	0.8668 mL	1.7336 mL	4.3340 mL
	50 mM	0.1387 mL	0.6934 mL	1.3869 mL	3.4672 mL
	60 mM	0.1156 mL	0.5779 mL	1.1557 mL	2.8893 mL
	80 mM	0.0867 mL	0.4334 mL	0.8668 mL	2.1670 mL
	100 mM	0.0693 mL	0.3467 mL	0.6934 mL	1.7336 mL

Keywords

Octanoic acid

3 Cited Publications

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Octanoic acid

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Publications Citing Use of MedChemExpress (MCE) Octanoic acid

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Publications (3)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Octanoic acid Related Classifications

Cat. No.: HY-41417