Garsevil
Garsevil (LSL 60101) is a biphasic, selective imidazoline I2 receptor (I2-IR) ligand, with a pKi of 9.03 and a Ki of 0.9 nM at the high-affinity site, and a pKi of 5.25 and a Ki of 5.6 nM at the low-affinity site. Garsevil is applicable to research related to Alzheimer's disease.
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- CAS No.: 150985-54-9
- Formule: C11H8N2O
- Masse moléculaire:184.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Garsevil exhibits excellent selectivity for I2-IR over α2-adrenergic receptors (α2-AR), with an I2/α2 selectivity ratio of 7244.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 150985-54-9
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Masse moléculaire 184.20
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Formule C11H8N2O
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SMILES
N=1C=CNC1C=2OC=3C=CC=CC3C2
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Synonyms
LSL 60101
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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- Garsevil
- 150985-54-9
- LSL 60101
- LSL60101
- LSL-60101
- neuroinflammatory gene expression
- α2-adrenergic receptors
- alzheimer’s disease
- adult Sprague-Dawley rats
- human I2-IR
- imidazoline I2 receptor
- human prefrontal cortex I2-imidazoline receptors
- hippocampal FADD protein
- 5-month-old female 5xFAD mice
- adult CD-1 mice
- Inhibitor
- inhibitor
- inhibit