ALOX12 - arachidonate 12-lipoxygenase, 12S type Gene

Also Known as LOG12; 12-LOX; 12S-LOX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 239

About ALOX12

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:6,996,049-7,010,754 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues and 5 paralogues. Broad expression in esophagus (RPKM 11.1), skin (RPKM 5.2) and 15 other tissues.

Summary

This gene encodes a member of the Lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

ALOX12 Products (2)

mRNA	Protein	Name
NM_000697.3	NP_000688.2	polyunsaturated fatty acid lipoxygenase ALOX12
XM_011523780.3	XP_011522082.2	polyunsaturated fatty acid lipoxygenase ALOX12 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables arachidonate 12(S)-lipoxygenase activity	IDA IDA: Inferred from direct assay	1851637	GOA
enables arachidonate 15-lipoxygenase activity	IDA IDA: Inferred from direct assay	17493578	GOA
enables linoleate 13S-lipoxygenase activity	IDA IDA: Inferred from direct assay	8319693	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10727209	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in arachidonate metabolic process	IDA IDA: Inferred from direct assay	1851637	GOA
involved in fatty acid oxidation	IDA IDA: Inferred from direct assay	17493578	GOA
involved in fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	15111312	GOA
NOT involved in leukotriene A4 metabolic process	IDA IDA: Inferred from direct assay	1851637	GOA
involved in leukotriene A4 metabolic process	IDA IDA: Inferred from direct assay	8250832	GOA
NOT involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	1851637	GOA
involved in linoleic acid metabolic process	IDA IDA: Inferred from direct assay	8319693	GOA
involved in lipid metabolic process	IDA IDA: Inferred from direct assay	17493578	GOA
involved in lipoxin A4 biosynthetic process	IDA IDA: Inferred from direct assay	8250832	GOA
involved in lipoxin B4 biosynthetic process	IDA IDA: Inferred from direct assay	8250832	GOA
involved in lipoxygenase pathway	IDA IDA: Inferred from direct assay	8319693	GOA
involved in negative regulation of muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23578768	GOA
involved in unsaturated fatty acid metabolic process	IDA IDA: Inferred from direct assay	23504711	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8319693	GOA
located in cytosol	IDA IDA: Inferred from direct assay	8912711	GOA
located in membrane	IDA IDA: Inferred from direct assay	8912711	GOA
located in sarcolemma	IDA IDA: Inferred from direct assay	15107407	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALOX12 Protein Structure

PLAT

Lipoxygenase

0
200
400
600
663 a.a.

Protein Preferred Names	Protein Names
polyunsaturated fatty acid lipoxygenase ALOX12	12S-lipoxygenase Arachidonate 12-lipoxygenase, 12S-type arachidonate (12S)-lipoxygenase arachidonate (15S)-lipoxygenase arachidonate 15-lipoxygenase,15S-type linoleate 13S-lipoxygenase lipoxin synthase 12-LO platelet 12-LOX platelet-type 12-lipoxygenase platelet-type lipoxygenase 12

ALOX12 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ALOX12	P18054	LMNA	Homo sapiens	P02545	Anti Bait CoIP	10727209
Intra	ALOX12	P18054	LMNA	Homo sapiens	P02545	Y2H	10727209
Intra	ALOX12	P18054	KRT5	Homo sapiens	P13647	Y2H	10727209
Intra	ALOX12	P18054	KRT5	Homo sapiens	P13647	Anti Bait CoIP	10727209

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ALOX12 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P72076	ALOX12 Protein, Human (His)	P18054 (M1-I663)	≥ 90%, as determined by reducing SDS-PAGE.

ALOX12 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82293	12 Lipoxygenase Antibody (YA2038)	WB	Human, Rat

Related Diseases

Diseases	Alias
Erythroleukemia
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Squamous Cell Skin Cancer Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Diabetes Mellitus, Non-Insulin-Dependent Type 2 Diabetes T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Adenoma	Acinar Cell Adenoma Adenomas Acinic Cell Adenoma
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Psoriasis
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Toxoplasmosis	Disseminated Toxoplasmosis Multisystemic Disseminated Toxoplasmosis Acquired Toxoplasmosis Toxoplasmosis Disease Or Disorder Infection By Toxoplasma Gondii Toxoplasmal Toxoplasma
Ichthyosis, Congenital, Autosomal Recessive 3	Autosomal Recessive Congenital Ichthyosis 3 ARCI3 Lamellar Ichthyosis 5 Collodion Baby, Self-Healing Ichthyosis, Lamellar, 5, Formerly Li5, Formerly Li5 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 3
Diabetes Mellitus	Diabetes
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-150191	IMA-1		/	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS00613	Alox12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113509B	15(R)-Lipoxin A4		98.3%	Unkown
HY-RS00612	ALOX12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00614	Alox12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00615	ALOX12B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00618	Alox15 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALOX12	RGD	RGD:1311159
Canis familiaris	ALOX12	VGNC	VGNC:49900
Macaca mulatta	ALOX12	VGNC	VGNC:69795
Mus musculus	ALOX12	MGD	MGI:87998
Bos taurus	ALOX12	VGNC	VGNC:25841
Others	ALOX12	NCBI