BRSK2 - BR serine/threonine kinase 2 Gene

Also Known as SAD1; SADA; SAD-A; STK29; PEN11B; C11orf7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9024

About BRSK2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,389,934-1,462,689 (from NCBI)

This gene has 15 transcripts (splice variants), 308 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in brain (RPKM 8.8), pancreas (RPKM 3.6) and 2 other tissues.

Summary

Enables several functions, including ATP binding activity; ATPase binding activity; and protein kinase activity. Involved in several processes, including cellular protein metabolic process; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

BRSK2 Products (5)

mRNA Protein Name
NM_001256627.2 NP_001243556.1 serine/threonine-protein kinase BRSK2 isoform 1
NM_001256629.2 NP_001243558.1 serine/threonine-protein kinase BRSK2 isoform 3
NM_001256630.1 NP_001243559.1 serine/threonine-protein kinase BRSK2 isoform 4
NM_001282218.2 NP_001269147.1 serine/threonine-protein kinase BRSK2 isoform 5
NM_003957.4 NP_003948.2 serine/threonine-protein kinase BRSK2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables ATP binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables ATPase binding IDA
IDA: Inferred from direct assay
23907667 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
14976552 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22609399 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
14976552 GOA
enables tau-protein kinase activity IDA
IDA: Inferred from direct assay
21985311 GOA
Biological Process GO Annotation Evidence Références Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
23907667 GOA
involved in G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
23029325 GOA
involved in actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
22669945 GOA
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
IMP: Inferred from mutant phenotype
22713462 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
14976552 GOA
involved in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
22669945 GOA
Cellular Component GO Annotation Evidence Références Source
located in centrosome IDA
IDA: Inferred from direct assay
23029325 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
22713462 GOA
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
23907667 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRSK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (19 - 269)

  • 0
  • 200
  • 400
  • 600
  • 736 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase BRSK2

  • BR serine/threonine-protein kinase 2

BRSK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
BRSK2 Q8IWQ3 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Autosomal Dominant Non-Syndromic Intellectual Disability
Carrion'S Disease

  • Oroya Fever

  • Carrion Disease

  • Bartonellosis Due To Bartonella Bacilliformis Infection

  • Bartonella Infections

  • Systemic Bartonellosis Due To Bartonella Bacilliformis

  • Systemic Carrión Disease

  • Systemic Bartonellosis

  • Bartonella Fever
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS23792 Brsk2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BRSK2 VGNC VGNC:70291
Felis catus BRSK2 VGNC VGNC:60185
Bos taurus BRSK2 VGNC VGNC:56257
Rattus norvegicus BRSK2 RGD RGD:1566256
Mus musculus BRSK2 MGD MGI:1923020
Canis familiaris BRSK2 VGNC VGNC:51843
Others BRSK2 NCBI