Cat. No.: HY-W071746

Linolelaidic acid

(Synonyms: Linoelaidic acid)

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Linolelaidic acid (Linoelaidic acid) is an omega-6 trans fatty acid (TFA) that is an essential nutrient with oral activity. Linolelaidic acid can be added to enteral nutrition (oral), parenteral nutrition (intravenous), and infant formula. Linolelaidic acid has anti-inflammatory and anti-parasitic ((Parasite)) activities, and can induce Apoptosis. Linolelaidic acid is useful for research in infections.

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Pureté: 99.96%
CAS No.: 506-21-8
Formule: C₁₈H₃₂O₂
Masse moléculaire:280.45

Stockage:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Linolelaidic acid Chemical Structure

CAS No.: 506-21-8

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Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

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Voir tous les produits spécifiques à Isoform Parasite :

In Vitro

Linolenic Acid shows inhibitory activity against P. falciparum strains D10 (the chloroquine sensitive strain) and Dd2 (the chloroquine resistant strain), with IC₅₀ values of 4.12 μg/mL and 5.04 μg/mL, respectively^[2].
Linolelaidic acid (50 μM, 24 h) induces apoptosis, cell cycle arrest andinﬂammation in human umbilicalvein endothelial cells through lipid rafts^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[3]

Cell Line:

Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration:

50 μM
Incubation Time:

24 h
Result:

Resulted in a significant decrease in cell viability.

Apoptosis Analysis^[3]

Cell Line:

Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration:

50 μM
Incubation Time:

24 h
Result:

Resulted in a significant increase in the number of apoptotic cells and the cell population in the G1 phase.

Western Blot Analysis^[3]

Cell Line:

Human umbilicalvein endothelial cells (HUVECs) (Methyl-β-cyclodextrin (HY-101461)-induced lipid raft disruption model)
Concentration:

50 μM
Incubation Time:

24 h
Result:

Led to a significant increase in the expression levels of pro-apoptotic proteins (caspase-3, -8, Bax, p53) and inflammatory factors (vascular cell adhesion molecule-1, intercellular adhesion molecule, E-selectin, and nitric oxide), while the expression level of the anti-apoptotic protein Bcl-2 was significantly decreased.

In Vivo

Linolenic Acid (10 mg/kg, p.o., once daily for 4 days) shows anti-parasitic activity in the P. berghei (ANKA) strain-induced malaria C57BL/6 mouse model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

P. berghei (ANKA) strain-induced malaria C57BL/6 mice model (7-to-10-week old)^[3]
Dosage:

10 mg/kg
Administration:

Oral gavage (p.o.), once daily for 4 days
Result:

Inhibited the growth of P. berghei by 70%.

Animal Model:

High-fat diet-fed streptozotocin (HFD-STZ) rat model^[2]
Dosage:

500 μg/kg
Administration:

Oral gavage (p.o.), once daily for 4 weeks, 30 min myocardial ischemia followed by 4 or 6 h reperfusion after 4 weeks
Result:

Significantly improved the instantaneous first derivation of left ventricle pressure, reduced infarct size, plasma creatine kinase and lactate dehydrogenase activities, and apotosis at the end of reperfusion in HFD-STZ diabetic rats.
Not only significantly reduced tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) concentrations but reduced the increase in superoxide production and malonaldialdehyde formation and simultaneously enhanced the antioxidant capacity in the diabetic hearts.
Increased myocardial PI3K expression and Akt phosphorylation in diabetic but not normal rats.

Chemical Information

CAS No. 506-21-8
Appearance Liquid (Density: 0.89 g/cm³)
Masse moléculaire 280.45
Formule C₁₈H₃₂O₂
Color Colorless to light yellow
SMILES

CCCCC/C=C/C/C=C/CCCCCCCC(O)=O
Synonyms

Linoelaidic acid
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227

Solvant et solubilité

In Vitro:

DMSO : 125 mg/mL (445.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.5657 mL

17.8285 mL

35.6570 mL

5 mM

0.7131 mL

3.5657 mL

7.1314 mL

10 mM

0.3566 mL

1.7828 mL

3.5657 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jay Whelan, et al. Linoleic acid. Adv Nutr. 2013 May 1;4(3):311-2. [Content Brief]

[2]. Melariri P, et al. In vitro and in vivo antimalarial activity of linolenic and linoleic acids and their methyl esters[J]. Adv Stud Biol, 2012, 4(7): 333-49.

[3]. Li J, et al. Linolelaidic acid induces apoptosis, cell cycle arrest and inflammation stronger than elaidic acid in human umbilical vein endothelial cells through lipid rafts[J]. European Journal of Lipid Science and Technology, 2017, 119(7): 1600374.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.5657 mL	17.8285 mL	35.6570 mL	89.1424 mL
	5 mM	0.7131 mL	3.5657 mL	7.1314 mL	17.8285 mL
	10 mM	0.3566 mL	1.7828 mL	3.5657 mL	8.9142 mL
	15 mM	0.2377 mL	1.1886 mL	2.3771 mL	5.9428 mL
	20 mM	0.1783 mL	0.8914 mL	1.7828 mL	4.4571 mL
	25 mM	0.1426 mL	0.7131 mL	1.4263 mL	3.5657 mL
	30 mM	0.1189 mL	0.5943 mL	1.1886 mL	2.9714 mL
	40 mM	0.0891 mL	0.4457 mL	0.8914 mL	2.2286 mL
	50 mM	0.0713 mL	0.3566 mL	0.7131 mL	1.7828 mL
	60 mM	0.0594 mL	0.2971 mL	0.5943 mL	1.4857 mL
	80 mM	0.0446 mL	0.2229 mL	0.4457 mL	1.1143 mL
	100 mM	0.0357 mL	0.1783 mL	0.3566 mL	0.8914 mL

Keywords

Linolelaidic acid

1 Cited Publications

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Linolelaidic acid

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Voir tous les produits spécifiques à Isoform Endogenous Metabolite

Voir tous les produits spécifiques à Isoform Parasite

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Linolelaidic acid Related Classifications

HY-W071746 Related Classifications