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Cat. No.: HY-187586

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Mdl 28815

Mdl 28815 is an inhibitor of Sterol-delta 14-reductase and 2,3-oxido-squalene cyclase, with IC₅₀ values of 0.07 μM and 2 μM, respectively. Mdl 28815 blocks cholesterol biosynthesis and causes the accumulation of specific sterol metabolites. Mdl 28815 is applicable to research related to hypercholesterolemia.

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CAS No.: 104905-12-6
Formule: C₂₄H₄₇NO
Masse moléculaire:365.65

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Please store the product under the recommended conditions in the Certificate of Analysis.

Mdl 28815 Chemical Structure

CAS No.: 104905-12-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC50	0.07 μM	Inhibition of sterol Δ¹⁴-reductase (assessed via cholesterol biosynthesis inhibition and accumulation of Δ⁸,¹⁴-cholestadienol) in human hepatoblastoma HepG2 cells. Inhibition of sterol Δ¹⁴-reductase (assessed via cholesterol biosynthesis inhibition and accumulation of Δ⁸,¹⁴-cholestadienol) in human hepatoblastoma HepG2 cells.	1404239

In Vitro

Mdl 28815 blocks cholesterol biosynthesis in HepG2 cells primarily by inhibiting Sterol-delta 14-reductase (and possibly Sterol-delta 8-ene isomerase), rather than 2,3-oxidosqualene cyclase^[1].
Mdl 28815 (Compound 2b) inhibits sterol Δ¹⁴-reductase in HepG2 cells with an IC₅₀ of 0.07 μM, and also inhibits OSC^[2] in HepG2 cells.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 104905-12-6
Masse moléculaire 365.65
Formule C₂₄H₄₇NO
SMILES

C[C@]12[C@@](CCN(C(CCCC(CCCC(C)C)C)C)C1)([C@H](C)[C@@H](O)CC2)[H]
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Van Sickle WA, et al. An alternative mechanism for the inhibition of cholesterol biosynthesis in HepG2 cells by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol (MDL 28,815). The Journal of pharmacology and experimental therapeutics. 1993 Dec;267(3):1243-9.

[2]. Wannamaker MW, et al. N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase. J Med Chem. 1992 Sep 18;35(19):3581-3.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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