104905-12-6
104905-12-6
Chemical Structure
Mdl 28815
- CAS No.: 104905-12-6
- Formula:C24H47NO
- Molecular Weight:365.65
IUPAC Name: (4aS,5S,6S,8aS)-2-(6,10-dimethylundecan-2-yl)-5,8a-dimethyldecahydroisoquinolin-6-ol
InChIKey: YSACNAXEZHCMEQ-MEPSBQSWSA-N
SMILES: C[C@]12[C@@](CCN(C(CCCC(CCCC(C)C)C)C)C1)([C@H](C)[C@@H](O)CC2)[H]
Biological Activity: Mdl 28815 is an inhibitor of Sterol-delta 14-reductase and 2,3-oxido-squalene cyclase, with IC50 values of 0.07 μM and 2 μM, respectively. Mdl 28815 blocks cholesterol biosynthesis and causes the accumulation of specific sterol metabolites. Mdl 28815 is applicable to research related to hypercholesterolemia[1][2].
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Mdl 28815 | Mdl 28815 is an inhibitor of Sterol-delta 14-reductase and 2,3-oxido-squalene cyclase, with IC50 values of 0.07 μM and 2 μM, respectively. Mdl 28815 blocks cholesterol biosynthesis and causes the accumulation of specific sterol metabolites. Mdl 28815 is applicable to research related to hypercholesterolemia. | |||||||||||||||||||||
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References
- [1]. Van Sickle WA, et al. An alternative mechanism for the inhibition of cholesterol biosynthesis in HepG2 cells by N-[(1,5,9)-trimethyldecyl]-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol (MDL 28,815). The Journal of pharmacology and experimental therapeutics. 1993 Dec;267(3):1243-9.
- [2]. Wannamaker MW, et al. N-(1-oxododecyl)-4 alpha,10-dimethyl-8-aza-trans-decal-3 beta-ol: a potent competitive inhibitor of 2,3-oxidosqualene cyclase. J Med Chem. 1992 Sep 18;35(19):3581-3.
