Cat. No.: HY-122308

Militarine

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Militarine is a plant growth inhibitor and anti-inflammatory agent. Militarine inhibits the elongation of radicles and hypocotyls in seedlings of lettuce, Italian ryegrass and timothy grass. Militarine alleviates PM_2.5-induced inflammatory injury and inhibits cell migration in human alveolar epithelial A549 cells by inhibiting the NF-κB signaling pathway, reducing oxidative stress and the release of inflammatory factors. Militarine can be used in studies related to PM_2.5-induced pulmonary diseases.

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Pureté: 99.94%
CAS No.: 58139-23-4
Formule: C₃₄H₄₆O₁₇
Masse moléculaire:726.72

Stockage:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Militarine Chemical Structure

CAS No.: 58139-23-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

COX-2

IL-6

IL-1β

Voir tous les produits spécifiques à Isoform NF-κB :

Voir tous les produits spécifiques à Isoform Interleukin Related :

Voir tous les produits spécifiques à Isoform COX :

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	IC₅₀	>10 μM Compound: 43	Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release using MeO-Suc-Ala-Ala-Pro-Val-p-nitroanilide as elastase substrate preincubated for 5 mins followed by fMLP/CB-induction	[PMID: 27525452]
Neutrophil	IC₅₀	>10 μM Compound: 43	Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal Antiinflammatory activity in human neutrophils assessed as inhibition of FMLP/cytochalasin B-induced superoxide anion generation by measuring superoxide dismutase-inhibitable reduction of ferricytochrome c preincubated for 5 mins followed by FMLP/cytochal	[PMID: 27525452]

In Vitro

Militarine (52 h) inhibits the elongation of radicles and hypocotyls in seedlings of lettuce (Lactuca sativa L. cv. Great Lakes 366), with an EC₅₀ value of 0.28 mM for radicles and 1.03 mM for hypocotyls^[1].
Militarine (52 h) inhibits the elongation of radicles and hypocotyls in seedlings of Lolium multiflorum Lam., with an EC₅₀ value of 0.43 mM for radicles and 1.18 mM for hypocotyls^[1].
Militarine (58 h) inhibits the elongation of radicles and hypocotyls in Phleum pratense L. seedlings, with corresponding EC₅₀ values of 0.32 mM and 0.82 mM for radicles and hypocotyls, respectively^[1].
Militarine (1.25-60 μg/mL; 24 h) reduces the viability of A549 cells^[2].
Militarine (1.25-10 μg/mL; 20 h) reduces the secretion levels of IL-6 and TNF-α in A549 cells exposed to PM_2.5^[2].
Militarine (1.25-10 μg/mL; 20 h) inhibits the mRNA expression of IL-6, TNF-α, IL-1β and COX-2, and reduces the accumulation level of ROS in PM_2.5-exposed A549 cells^[2].
Militarine (1.25-10 μg/mL; 20 h) reduces the apoptosis level of A549 cells after PM_2.5 exposure, and inhibits cell migration and invasion^[2].
Militarine (1.25-10 μg/mL; 20 h) inhibits the activation of the NF-κB pathway by reducing the phosphorylation levels of IKKβ, IκBα and NF-κBp65 in A549 cells exposed to PM_2.5; in addition, 5 and 10 μg/mL Militarine reduces the COX-2 protein level in PM_2.5-exposed cells after 18 h of exposure^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

human lung alveolar epithelial A549 cells
Concentration:

1.25, 2.5, 5, 10, 20, 40, 60 μg/mL
Incubation Time:

24 h
Result:

Exerted a marked inhibitory effect on A549 cell viability at 20, 40 and 60 μg/mL.

ELISA Assay^[2]

Cell Line:

PM₂.₅-exposed human lung alveolar epithelial A549 cells
Concentration:

1.25, 2.5, 5, 10 μg/mL
Incubation Time:

2 h (pretreatment); 18 h (PM₂.₅ exposure)
Result:

Significantly decreased IL-6 content relative to the PM₂.₅-only group at all tested concentrations.
Significantly decreased TNF-α content relative to the PM₂.₅-only group at 5 and 10 μg/mL.

Chemical Information

CAS No. 58139-23-4
Appearance Solid
Masse moléculaire 726.72
Formule C₃₄H₄₆O₁₇
Color White to light yellow
SMILES

O[C@H]([C@H]1O)[C@@H](O[C@@H]([C@H]1O)CO)OC(C=C2)=CC=C2COC([C@](CC(C)C)(O)CC(OCC(C=C3)=CC=C3O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO)=O)=O
Structure Classification
- Phenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Publications (1)

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Metabolism

Hepatocyte DDIT4 aggravates MASH progression through GPX4-mediated ferroptosis. [Abstract]

2026 Jul:180:156622. PMID: 41997496

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (137.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 50 mg/mL (68.80 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.3760 mL

6.8802 mL

13.7605 mL

5 mM

0.2752 mL

1.3760 mL

2.7521 mL

10 mM

0.1376 mL

0.6880 mL

1.3760 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sakuno E, et al. Contribution of militarine and dactylorhin A to the plant growth‐inhibitory activity of a weed‐suppressing orchid, Bletilla striata. Weed biology and management, 2010, 10(3): 202-207.

[2]. Cheng W, et al. Inhibition of inflammation-induced injury and cell migration by coelonin and militarine in PM_2.5-exposed human lung alveolar epithelial A549 cells. Eur J Pharmacol. 2021;896:173931. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	1.3760 mL	6.8802 mL	13.7605 mL	34.4011 mL
	5 mM	0.2752 mL	1.3760 mL	2.7521 mL	6.8802 mL
	10 mM	0.1376 mL	0.6880 mL	1.3760 mL	3.4401 mL
	15 mM	0.0917 mL	0.4587 mL	0.9174 mL	2.2934 mL
	20 mM	0.0688 mL	0.3440 mL	0.6880 mL	1.7201 mL
	25 mM	0.0550 mL	0.2752 mL	0.5504 mL	1.3760 mL
	30 mM	0.0459 mL	0.2293 mL	0.4587 mL	1.1467 mL
	40 mM	0.0344 mL	0.1720 mL	0.3440 mL	0.8600 mL
	50 mM	0.0275 mL	0.1376 mL	0.2752 mL	0.6880 mL
	60 mM	0.0229 mL	0.1147 mL	0.2293 mL	0.5734 mL
DMSO	80 mM	0.0172 mL	0.0860 mL	0.1720 mL	0.4300 mL
DMSO	100 mM	0.0138 mL	0.0688 mL	0.1376 mL	0.3440 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Militarine

1 Cited Publications

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Militarine

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Publications Citing Use of MedChemExpress (MCE) Militarine

Voir tous les produits spécifiques à Isoform NF-κB

Voir tous les produits spécifiques à Isoform Interleukin Related

Voir tous les produits spécifiques à Isoform COX

Activité biologique

Chemical Information

Publications (1)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Militarine Related Classifications

HY-122308 Related Classifications