XAT-13
XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3107904-58-2
- Formule: C20H16O5
- Masse moléculaire:336.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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MRGPRX2 |
XAT-13 (up to 100 μmol/L) shows no cytotoxicity in LAD2 cells[1].
XAT-13 (25-100 μmol/L) inhibits C48/80-induced β-hexosaminidase release from LAD2 cells in a dose-dependent manner, with an IC50 of 57.27 ± 0.13 μmol/L, and is more potent than Imperatorin (HY-N0285)[1].
XAT-13 (25-100 μmol/L) dose-dependently inhibits C48/80-induced intracellular calcium influx in MRGPRX2-HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C48/80-induced local allergy[1]
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Dosage:4, 8, 16 mg/kg
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Administration:p.o.
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Result:Attenuated the hind paws thickness.
Resulted in statistically significant differences in serum histamine levels.
Chemical Information
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CAS No. 3107904-58-2
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Masse moléculaire 336.34
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Formule C20H16O5
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SMILES
O=C1OC2=C(OCCCOC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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