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Art. -Nr.: HY-106234

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ZP 120C

ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia.

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CAS. Nr.: 383123-18-0
Formel: C₈₅HN₂₇O₁₅
Molecular Weight:1781.20

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZP 120C Chemical Structure

CAS. Nr.: 383123-18-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

ZP 120C is a potent and partial ORL1 receptor agonist. ZP 120C inhibits electrically induced contraction. ZP 120C can be used in the research of hyponatremia/hypokalemia^[1]^[3].

IC₅₀ & Target^[1]

NOP Receptor/ORL1

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen :

In Vitro

ZP 120C (1 nM) inhibits electrically induced contraction of the mouse vas deferen^[2].
ZP 120C (1 μM) inhibits electrical field stimulation (EFS)-induced contractions in rat arteries^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ZP 120C (1 nM/kg/min, i.v., 2.5 h) displays an aquaretic effect in conscious, chronically instrumented rats with congestive heart failure (CHF)^[1]
. ZP 120C (1 nM, i.c.v., 30 min) produces pronociceptive effects in the tail withdrawal assay and decreases locomotor activity in mice^[2]
.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Rats induced by left coronary artery ligation (LCAL)^[1]
Dosage:

1 nM/kg/min
Administration:

Intravenous injection (i.v.), 2.5 h of constant intravenous infusion
Result:

Increased diuresis, free water clearance, fractional water excretion, and fractional distal water excretion.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 383123-18-0
Molecular Weight 1781.20
Formel C₈₅HN₂₇O₁₅
Sequence Shortening

Ac-RYYRWKKKKKKK-NH2
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Hadrup N, et al. Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation. Am J Physiol Renal Physiol. 2004 Jul;287(1):F160-8. [Content Brief]

[2]. Rizzi A, et al. Pharmacological characterization of the novel nociceptin/orphanin FQ receptor ligand, ZP120: in vitro and in vivo studies in mice. Br J Pharmacol. 2002 Oct;137(3):369-74. [Content Brief]

[3]. Simonsen U, et al. ZP120 causes relaxation by pre-junctional inhibition of noradrenergic neurotransmission in rat mesenteric resistance arteries. Br J Pharmacol. 2008 Mar;153(6):1185-94. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Reinheit & Dokumentation
Verweise

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ZP 120C

Alle Opioid Receptor Isoform-spezifische Produkte anzeigen