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Cat. No.: HY-168967

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BAY-277

BAY-277 is a selective METAP2 degrader and inhibitor. BAY-277 induces ubiquitination and proteasomal degradation of METAP2, triggers G1-phase cell cycle arrest, and inhibits angiogenesis and endothelial cell proliferation. BAY-277 serves as a chemical probe for investigating the biological functions of METAP2. BAY-277 is applicable to cancer-related research.

For research use only. We do not sell to patients.

Formula: C₄₄H₅₂N₈O₅
Molecular Weight:772.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (249 KB)

BAY-277 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

MetAp2

All MetAP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HT-1080	DC₅₀	8.93 nM Compound: EUB0003014	Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE)) Degradation in HT1080 cells (CE) (Capillary electrophoresis (CE))	10.6019/CHEMBL5463725
HUVEC	DC₅₀	0.2 nM Compound: EUB0003014	Degradation in HUVEC cells (WB) (Western Blot (WB)) Degradation in HUVEC cells (WB) (Western Blot (WB))	10.6019/CHEMBL5463725
HUVEC	IC₅₀	12 nM Compound: EUB0003014	2D HUVEC cells proliferation assay 2D HUVEC cells proliferation assay	10.6019/CHEMBL5463725

In Vitro

BAY-277 degrades METAP2 in human umbilical vein endothelial cells (HUVEC) and HT1080 fibrosarcoma cells.
BAY-277 potently inhibits the enzymatic activity of recombinant human METAP2.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 772.93
Formula C₄₄H₅₂N₈O₅
SMILES

O=C(N1CCC(C2=CC=C3C(CN(C4C(NC(CC4)=O)=O)C3=O)=C2)CC1)CCCCCN(CC5)CCC5C6=CC=C(C=C6)OC7=NN8C(C9=C7CCCC9)=NN=C8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.