Fenbuconazole
Based on 1 Customer Validation
Fenbuconazole is a triazole fungicide that has fungicidal activity through inhibiting sterol biosynthesis. Fenbuconazole is an inhibitor of human aromatase activity in human choriocarcinoma JEG-3 cell line. Fenbuconazole can result in a significant increase in DNA damage in Allium cepa root cells. Fenbuconazole significantly increases the abnormal cell frequency in vitro. Fenbuconazole exhibits ED50 of 0.21 μg/mL with M.citri and 1.01 μg/mL with C. acutatum.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 114369-43-6
- Formula: C19H17ClN4
- Molecular Weight:336.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Chemical Information
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CAS No. 114369-43-6
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Appearance Solid
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Molecular Weight 336.83
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Formula C19H17ClN4
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Color White to off-white
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SMILES
C1=CC=C(C=C1)C(CCC2=CC=C(C=C2)Cl)(C#N)CN3C=NC=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (296.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (459 KB)
- English - EN (459 KB)
- Français - FR (459 KB)
- Deutsch - DE (459 KB)
- Norwegian - NO (459 KB)
- Español - ES (459 KB)
- Swedish - SV (459 KB)
- Italian - IT (459 KB)
- Korean - KR (459 KB)
- Portuguese - PT (459 KB)
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Handling Instructions (2659 KB)
References
[1]. Tao Y, et al., Supercritical fluid chromatography-tandem mass spectrometry-assisted methodology for rapid enantiomeric analysis of fenbuconazole and its chiral metabolites in fruits, vegetables, cereals, and soil. Food Chem. 2018 Feb 15;241:32-39. [Content Brief]
[2]. Mondal SN, et al., Baseline Sensitivities of Fungal Pathogens of Fruit and Foliage of Citrus to Azoxystrobin, Pyraclostrobin, and Fenbuconazole. Plant Dis. 2005 Nov;89(11):1186-1194. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9689 mL | 14.8443 mL | 29.6886 mL | 74.2214 mL |
| 5 mM | 0.5938 mL | 2.9689 mL | 5.9377 mL | 14.8443 mL | |
| 10 mM | 0.2969 mL | 1.4844 mL | 2.9689 mL | 7.4221 mL | |
| 15 mM | 0.1979 mL | 0.9896 mL | 1.9792 mL | 4.9481 mL | |
| 20 mM | 0.1484 mL | 0.7422 mL | 1.4844 mL | 3.7111 mL | |
| 25 mM | 0.1188 mL | 0.5938 mL | 1.1875 mL | 2.9689 mL | |
| 30 mM | 0.0990 mL | 0.4948 mL | 0.9896 mL | 2.4740 mL | |
| 40 mM | 0.0742 mL | 0.3711 mL | 0.7422 mL | 1.8555 mL | |
| 50 mM | 0.0594 mL | 0.2969 mL | 0.5938 mL | 1.4844 mL | |
| 60 mM | 0.0495 mL | 0.2474 mL | 0.4948 mL | 1.2370 mL | |
| 80 mM | 0.0371 mL | 0.1856 mL | 0.3711 mL | 0.9278 mL | |
| 100 mM | 0.0297 mL | 0.1484 mL | 0.2969 mL | 0.7422 mL |
Fenbuconazole Related Classifications
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