DIS3L - DIS3 like exosome 3'-5' exoribonuclease Gene

Also Known as DIS3L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115752

About DIS3L

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:66,293,309-66,333,898 (from NCBI)

This gene has 14 transcripts (splice variants), 196 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 7.4), testis (RPKM 7.4) and 25 other tissues.

Summary

The cytoplasmic RNA exosome complex degrades unstable mRNAs and is involved in the regular turnover of Other mRNAs. The protein encoded by this gene contains 3'-5' exoribonuclease activity and is a catalytic component of this complex. [provided by RefSeq, May 2016]

DIS3L Products (13)

mRNA Protein Name
NM_001143688.3 NP_001137160.1 DIS3-like exonuclease 1 isoform 1
NM_001323936.2 NP_001310865.1 DIS3-like exonuclease 1 isoform 2
NM_001323937.2 NP_001310866.1 DIS3-like exonuclease 1 isoform 5
NM_001323938.2 NP_001310867.1 DIS3-like exonuclease 1 isoform 3
NM_001323939.2 NP_001310868.1 DIS3-like exonuclease 1 isoform 3
NM_001323940.2 NP_001310869.1 DIS3-like exonuclease 1 isoform 4
NM_001323941.2 NP_001310870.1 DIS3-like exonuclease 1 isoform 3
NM_001323943.2 NP_001310872.1 DIS3-like exonuclease 1 isoform 4
NM_001323944.2 NP_001310873.1 DIS3-like exonuclease 1 isoform 6
NM_001323945.2 NP_001310874.1 DIS3-like exonuclease 1 isoform 2
NM_001323946.2 NP_001310875.1 DIS3-like exonuclease 1 isoform 3
NM_001323948.2 NP_001310877.1 DIS3-like exonuclease 1 isoform 7
NM_133375.5 NP_588616.1 DIS3-like exonuclease 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5'-RNA exonuclease activity IDA
IDA: Inferred from direct assay
20531389 GOA
enables 3'-5'-RNA exonuclease activity IMP
IMP: Inferred from mutant phenotype
20531386 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
20531386 GOA
enables exoribonuclease II activity IDA
IDA: Inferred from direct assay
37602378 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20531386 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA catabolic process IDA
IDA: Inferred from direct assay
20531386 GOA
involved in RNA processing IDA
IDA: Inferred from direct assay
20531386 GOA
involved in rRNA catabolic process IDA
IDA: Inferred from direct assay
20531389 GOA
involved in rRNA catabolic process IMP
IMP: Inferred from mutant phenotype
20368444 GOA
Cellular Component GO Annotation Evidence References Source
part of cytoplasmic exosome (RNase complex) IDA
IDA: Inferred from direct assay
20531386 GOA
located in cytosol IDA
IDA: Inferred from direct assay
20531386 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIS3L Protein Structure

RNB

RNB: RNB domain (465 - 816)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1054 a.a.
Protein Preferred Names Protein Names

DIS3-like exonuclease 1

  • DIS3 mitotic control homolog-like

DIS3L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DIS3L Q8TF46 EXOSC3 Homo sapiens Q9NQT5
Anti Bait CoIP
20531386
Intra
DIS3L Q8TF46 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
23756462
Intra
DIS3L Q8TF46 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
33961781
Intra
DIS3L Q8TF46 EXOSC3 Homo sapiens Q9NQT5
Anti Tag CoIP
26496610
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Perlman Syndrome

  • Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor

  • PRLMNS

  • Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism

  • Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor

  • Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor

  • Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor

  • Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism

  • Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome

  • Renal Hamartomas Nephroblastomatosis And Fetal Gigantism

  • Nephroblastoma

  • Fetal Macrosomia
Trichohepatoenteric Syndrome 1

  • Trichohepatoenteric Syndrome

  • Syndromic Diarrhea

  • Tricho-Hepato-Enteric Syndrome

  • Sd/The

  • Syndromic Diarrhea/Tricho-Hepato-Enteric Syndrome

  • THES1

  • Phenotypic Diarrhea

  • Thes

  • Phenotypic Diarrhea Of Infancy

  • Diarrhea, Syndromic

  • Diarrhea, Fatal Infantile, With Trichorrhexis Nodosa

  • Intractable Diarrhea With Phenotypic Anomalies

  • Syndromatic Diarrhea

  • Fatal Infantile Diarrhea With Trichorrhexis Nodosa
Trichohepatoenteric Syndrome 2

  • THES2
Pontocerebellar Hypoplasia

  • Pch

  • Congenital Pontocerebellar Hypoplasia

  • Opch

  • Hypoplasia, Pontocerebellar

  • Pontoneocerebellar Hypoplasia

  • Nonsyndromic Pontocerebellar Hypoplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03779 DIS3L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03780 DIS3L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DIS3L MGD MGI:2143272
Bos taurus DIS3L VGNC VGNC:28073
Canis familiaris DIS3L VGNC VGNC:39963
Macaca mulatta DIS3L VGNC VGNC:71796
Rattus norvegicus DIS3L RGD RGD:1308959
Felis catus DIS3L VGNC VGNC:61500
Others DIS3L NCBI