STK17B - serine/threonine kinase 17b Gene

Also Known as DRAK2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9262

About STK17B

Cytogenetic location: 2q32.3 Genomic coordinates (GRCh38): 2:196,133,583-196,176,483 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 1 paralogue. Broad expression in bone marrow (RPKM 54.0), lymph node (RPKM 45.0) and 18 other tissues.

Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein phosphorylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

STK17B Products (1)

mRNA Protein Name
NM_004226.4 NP_004217.1 serine/threonine-protein kinase 17B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9786912 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9786912 GOA
Biological Process GO Annotation Evidence References Source
involved in intracellular signal transduction IDA
IDA: Inferred from direct assay
9786912 GOA
involved in positive regulation of fibroblast apoptotic process IMP
IMP: Inferred from mutant phenotype
9786912 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9786912 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
9786912 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STK17B Protein Structure

Pkinase

Pkinase: Protein kinase domain (36 - 293)

  • 0
  • 100
  • 200
  • 300
  • 372 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase 17B

  • DAP kinase-related apoptosis-inducing protein kinase 2

Related Diseases

Diseases Alias
Colon Squamous Cell Carcinoma

  • Colonic Epidermoid Carcinoma

  • Squamous Cell Carcinoma Of Colon

  • Squamous Cell Carcinoma Of The Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156350 SGC-STK17B-1 Inhibitor 98.53% Unkown
HY-148062 RSS0680 Degrader 99.85% Unkown
HY-186224 GW296115 / Unkown
HY-RS13925 STK17B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus STK17B VGNC VGNC:65778
Mus musculus STK17B MGD MGI:2138162
Macaca mulatta STK17B VGNC VGNC:110332
Rattus norvegicus STK17B RGD RGD:620457
Canis familiaris STK17B VGNC VGNC:46908
Bos taurus STK17B VGNC VGNC:35388
Others STK17B NCBI