DAP - death associated protein Gene

Also Known as DAP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1611

About DAP

Cytogenetic location: 5p15.2 Genomic coordinates (GRCh38): 5:10,679,230-10,761,234 (from NCBI)

This gene has 6 transcripts (splice variants), 167 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 62.5), urinary bladder (RPKM 56.2) and 25 other tissues.

Summary

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

DAP Products (2)

mRNA Protein Name
NM_001291963.2 NP_001278892.1 death-associated protein 1 isoform 1
NM_004394.3 NP_004385.1 death-associated protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables death domain binding IPI
IPI: Inferred from physical interaction
1087798 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
1087798 GOA
acts upstream of or within apoptotic process IGI
IGI: Inferred from genetic interaction
7828849 GOA
involved in apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
1087798 GOA
involved in cellular response to amino acid starvation IDA
IDA: Inferred from direct assay
20537536 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
1087798 GOA
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
1087798 GOA
involved in negative regulation of autophagy IMP
IMP: Inferred from mutant phenotype
20537536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DAP Protein Structure

DAP

DAP: Death-associated protein (12 - 102)

  • 0
  • 102 a.a.
Protein Preferred Names Protein Names

death-associated protein 1

  • DAP-1

DAP Antibodies

Cat. No. Product Name Application Reactivity
HY-P82896 DAP1 Antibody (YA2641) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P82896A DAP1 Antibody (YA2641)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Alpha-Thalassemia

  • Alpha Thalassemia

  • Alpha Thalassaemia

  • Alpha Plus Thalassemia

  • Thalassemia, Alpha-

  • Thalassemias, Alpha-

  • A-Thalassemia

  • Α-Thalassemia

  • A-THAL

  • Thalassemia

  • Alpha Thalassaemia Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-P10375 BMS-986189 Inhibitor 99.58% Phase 1

Pre-clinical Phase

Bioactive Molecules (85)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100714A D-AP5 Antagonist 99.94% Unkown
HY-P1070 Amylin, amide, human 98.33% Unkown
HY-P4931 Mca-KPLGL-Dap(Dnp)-AR-NH2 99.30% Unkown
HY-P1070A Amylin, amide, human TFA 98.76% Unkown
HY-W010922 Fmoc-Dap(Boc)-OH 99.98% Unkown
HY-175510 TREM2 agonist-5 Agonist 99.61% Unkown
HY-W010962 Fmoc-Dap(Alloc)-OH 99.84% Unkown
HY-78932A Dap-NE hydrochloride 99.99% Unkown
HY-78931 Boc-Dap-NE 99.96% Unkown
HY-P10086 TREM-1 inhibitory peptide GF9 Inhibitor 99.41% Unkown
HY-P10950A PD-L1 inhibitory peptide TFA Inhibitor 99.81% Unkown
HY-400913 Mal-L-Dap(Boc, t-BuOAc)-OH 95.20% Unkown
HY-P5524A C12-iE-DAP hydrochloride Agonist 96.59% Unkown
HY-W008325 Boc-L-Dap-OH 98.0% Unkown
HY-W047799 Boc-Dap(Boc)-OH 98.0% Unkown
HY-P5523A iE-DAP dihydrochloride 99.72% Unkown
HY-144022 16:0 DAP 99% Unkown
HY-W046355 Fmoc-D-Dap(Boc)-OH 99.56% Unkown
HY-138169 Fmoc-Dap(Mtt)-OH / Unkown
HY-151715 N3-D-Dap(Fmoc)-OH 99.96% Unkown
HY-164170 Photocaged DAP 98.13% Unkown
HY-W250408 Fmoc-NMe-Val-Val-Dil-Dap-OH 96.19% Unkown
HY-160795 Boc-NMe-Val-Val-Dil-Dap-OH 97.54% Unkown
HY-W014692 Boc-D-2,3-diaminopropionic acid ≥97.0% Unkown
HY-78931A (R,S,S,R,S)-Boc-Dap-NE 97.13% Unkown
HY-P4905 Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 Inhibitor 98.02% Unkown
HY-78932G Dap-NE hydrochloride (GMP) / Unkown
HY-130961 Boc-Val-Dil-Dap-OH 98.52% Unkown
HY-145800 Photocaged DAP TFA 99.86% Unkown
HY-151640 Fmoc-DAP-N3 98.49% Unkown
HY-P3120 Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 Substrate 96.30% Unkown
HY-78931B (S,S,S,S,R)-Boc-Dap-NE 99.80% Unkown
HY-78931C (S,S,R,S,R)-Boc-Dap-NE 99.78% Unkown
HY-78931E (R,S,R,S,R)-Boc-Dap-NE 98.74% Unkown
HY-78931F (R,S,S,S,R)-Boc-Dap-NE 99.56% Unkown
HY-78932 Dap-NE 99.49% Unkown
HY-78932C (2S,3R)-Dap-NE hydrochloride Inhibitor / Unkown
HY-78931G Boc-Dap-NE (GMP) / Unkown
HY-100714B L-AP5 Antagonist / Unkown
HY-100781 D-AP4 Antagonist / Unkown
HY-118316 GSK223 Inhibitor / Unkown
HY-121634 DAP-81 Inhibitor / Unkown
HY-130975 Boc-Val-Dil-Dap-Phe-OMe / Unkown
HY-130976 N-Boc-Val-Dil-Dap-Doe / Unkown
HY-143700 18:0 DAP 99.99% Unkown
HY-144020 14:0 DAP / Unkown
HY-148760 SGD-1882-Dap-Val / Unkown
HY-154981 Mal-L-Dap(Boc)-OSu / Unkown
HY-164787 N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine Inhibitor / Unkown
HY-179254 Mal-L-Dap(Boc, t-BuOAc)-Pfp Ester / Unkown
HY-180692 (S)-2-Acetamido-6-oxopimelic acid / Unkown
HY-184530A Flotufolastat Ga / Unkown
HY-P10775 BT1769 Antagonist / Unkown
HY-P10950 PD-L1 inhibitory peptide Inhibitor / Unkown
HY-P11249 Mr1.1[S4Dap, C16Pen] Inhibitor / Unkown
HY-P11330 L-Ala-D-Glu-m-DAP-D-Ala-D-Ala / Unkown
HY-P1274 ShK-Dap22 Inhibitor / Unkown
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / Unkown
HY-P3120A Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 TFA Substrate / Unkown
HY-P3477 Mca-PLA-Nva-Dap(Dnp)-AR-NH2 / Unkown
HY-P4931A Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA / Unkown
HY-P5523 iE-DAP / Unkown
HY-P5524 C12-iE-DAP Agonist / Unkown
HY-RS03525 DAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03526 DAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03914 DNPEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06506 IAPP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W109214 Fmoc-L-Dap(Boc,Me)-OH / Unkown
HY-W337644 Fmoc-L-Homoarg(Et)2-OH hydrochloride / Unkown
HY-107719 D-AP7 / Unkown
HY-151736 N3-L-Dap(Boc)-OH / Unkown
HY-151780 Fmoc-L-Dap(Pentynoyl)-OH / Unkown
HY-151781 Fmoc-L-Dap(Poc)-OH / Unkown
HY-151849 Z-L-Dap(N3)-OH / Unkown
HY-162819 Apoptosis inducer 26 Inducer / Unkown
HY-164867 Fmoc-L-Dap(NBSD)-OH / Unkown
HY-177991 Cylic-DAP / Unkown
HY-177992 Cyclic-di-DAP / Unkown
HY-179828 DLin-C-DAP / Unkown
HY-78932D (2R,3R)-Dap-NE hydrochloride Inhibitor / Unkown
HY-RS16934 Dap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17689 Iapp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21319 Dap3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23377 Dap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27838 Dap3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991220 AL002 Agonist 98.01% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DAP RGD RGD:620641
Bos taurus DAP VGNC VGNC:50122
Macaca mulatta DAP VGNC VGNC:71730
Mus musculus DAP MGD MGI:1918190
Others DAP NCBI