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STX4 - syntaxin 4 Gene

Also Known as STX4A; p35-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6810

About STX4

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,033,095-31,040,168 (from NCBI)

This gene has 17 transcripts (splice variants), 191 orthologues and 12 paralogues. Ubiquitous expression in spleen (RPKM 17.8), adrenal (RPKM 16.5) and 25 other tissues.

Summary

Enables sphingomyelin phosphodiesterase activator activity. Involved in several processes, including cornified envelope assembly; positive regulation of immune effector process; and positive regulation of protein localization. Located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and lamellipodium. Part of SNARE complex. Is active in glutamatergic synapse and postsynapse. [provided by Alliance of Genome Resources, Apr 2022]

STX4 Products (3)

mRNA	Protein	Name
NM_001272095.1	NP_001259024.1	syntaxin-4 isoform 1
NM_001272096.1	NP_001259025.1	syntaxin-4 isoform 2
NM_004604.5	NP_004595.2	syntaxin-4 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12130530	GOA
enables sphingomyelin phosphodiesterase activator activity	IMP IMP: Inferred from mutant phenotype	20956541	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	22226963	GOA
involved in cornified envelope assembly	IDA IDA: Inferred from direct assay	22226963	GOA
involved in long-term synaptic potentiation	IDA IDA: Inferred from direct assay	20434989	GOA
involved in organelle fusion	IDA IDA: Inferred from direct assay	20434989	GOA
involved in positive regulation of catalytic activity	IMP IMP: Inferred from mutant phenotype	20956541	GOA
involved in positive regulation of cell adhesion	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15351710	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in positive regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in positive regulation of eosinophil degranulation	IMP IMP: Inferred from mutant phenotype	16677249	GOA
involved in positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	24055037	GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	24552216	GOA
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	12855681	GOA
involved in positive regulation of protein localization to cell surface	IMP IMP: Inferred from mutant phenotype	21720706	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	15351710	GOA
involved in regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	20434989	GOA
involved in regulation of extrinsic apoptotic signaling pathway via death domain receptors	IMP IMP: Inferred from mutant phenotype	20956541	GOA
involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	36355422	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	12130530	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16339081	GOA
located in cell surface	IDA IDA: Inferred from direct assay	15576373	GOA
located in dendritic spine	IDA IDA: Inferred from direct assay	20434989	GOA
located in endosome	IDA IDA: Inferred from direct assay	20956541	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	22226963	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27662481	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27662481	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	21720706	GOA
located in membrane	IDA IDA: Inferred from direct assay	7690687	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	20956541	GOA
is active in postsynapse	IDA IDA: Inferred from direct assay	27662481	GOA
is active in postsynapse	IMP IMP: Inferred from mutant phenotype	27662481	GOA
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	20434989	GOA
located in specific granule	IDA IDA: Inferred from direct assay	18588921	GOA
located in synapse	IDA IDA: Inferred from direct assay	20434989	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STX4 Protein Structure

Syntaxin

SNARE

0
100
200
297 a.a.

Protein Preferred Names	Protein Names
syntaxin-4	renal carcinoma antigen NY-REN-31

STX4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	STX4	Q12846	VAMP5	Homo sapiens	O95183	Y2H Array	32296183
Intra	STX4	Q12846	VAMP5	Homo sapiens	O95183	Y2H Prey Pooling	32296183
Intra	STX4	Q12846	SNAP47	Homo sapiens	Q5SQN1	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	SNAP47	Homo sapiens	Q5SQN1	Y2H Array	25416956
Intra	STX4	Q12846	SNAP47	Homo sapiens	Q5SQN1	Validated Y2H	25416956
Intra	STX4	Q12846	TMEM199	Homo sapiens	Q8N511	Validated Y2H	32296183
Intra	STX4	Q12846	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	STX4	Q12846	SGPL1	Homo sapiens	O95470	Y2H Prey Pooling	32296183
Intra	STX4	Q12846	SGPL1	Homo sapiens	O95470	Y2H Array	32296183
Intra	STX4	Q12846	SEC22B	Homo sapiens	O75396	Anti Bait CoIP	22153078
Intra	STX4	Q12846	ABI2	Homo sapiens	Q9NYB9-2	Validated Y2H	32296183
Intra	STX4	Q12846	TCEANC	Homo sapiens	Q8N8B7-2	Validated Y2H	32296183
Intra	STX4	Q12846	ANKRD46	Homo sapiens	Q86W74-2	Validated Y2H	32296183
Intra	STX4	Q12846	FAXDC2	Homo sapiens	Q96IV6	Validated Y2H	32296183
Intra	STX4	Q12846	PLP1	Homo sapiens	P60201-2	Y2H Array	32296183
Intra	STX4	Q12846	PLP1	Homo sapiens	P60201-2	Y2H Prey Pooling	32296183
Intra	STX4	Q12846	TMEM203	Homo sapiens	Q969S6	Validated Y2H	32296183
Intra	STX4	Q12846	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	STX4	Q12846	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	STX4	Q12846	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	STX4	Q12846	STX3	Homo sapiens	Q13277	Y2H Array	29892012
Intra	STX4	Q12846	STX3	Homo sapiens	Q13277	Y2H Array	31515488
Intra	STX4	Q12846	STX3	Homo sapiens	Q13277	Validated Y2H	32296183
Intra	STX4	Q12846	STX3	Homo sapiens	Q13277	Y2H Array	25416956
Intra	STX4	Q12846	STX3	Homo sapiens	Q13277	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	RNF4	Homo sapiens	P78317	Y2H Prey Pooling	32296183
Intra	STX4	Q12846	RNF4	Homo sapiens	P78317	Y2H Array	32296183
Cross	STX4	Q12846	ap3a_sars2	SARS-CoV-2	P0DTC3	Confocal	34706264
Cross	STX4	Q12846	ap3a_sars2	SARS-CoV-2	P0DTC3	Anti Tag CoIP	34706264
Intra	STX4	Q12846	STX12	Homo sapiens	Q86Y82	Y2H Array	31515488
Intra	STX4	Q12846	STX12	Homo sapiens	Q86Y82	Validated Y2H	25416956
Intra	STX4	Q12846	STX12	Homo sapiens	Q86Y82	Validated Y2H	32296183
Intra	STX4	Q12846	STX12	Homo sapiens	Q86Y82	Y2H Array	25416956
Intra	STX4	Q12846	STX6	Homo sapiens	O43752	Validated Y2H	25416956
Intra	STX4	Q12846	STX6	Homo sapiens	O43752	Y2H Array	25416956
Intra	STX4	Q12846	STX6	Homo sapiens	O43752	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	STX6	Homo sapiens	O43752	Y2H	21516116
Intra	STX4	Q12846	STX16	Homo sapiens	O14662	Y2H Array	25416956
Intra	STX4	Q12846	STX16	Homo sapiens	O14662	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	STX16	Homo sapiens	O14662	Validated Y2H	25416956
Intra	STX4	Q12846	STX7	Homo sapiens	O15400	Validated Y2H	25416956
Intra	STX4	Q12846	STX7	Homo sapiens	O15400	Y2H	21516116
Intra	STX4	Q12846	PSMA3	Homo sapiens	P25788	Y2H Array	25416956
Intra	STX4	Q12846	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	STX4	Q12846	NAPB	Homo sapiens	Q9H115	Validated Y2H	32296183
Intra	STX4	Q12846	GOSR2	Homo sapiens	O14653	Validated Y2H	25416956
Intra	STX4	Q12846	GOSR2	Homo sapiens	O14653	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	VAMP2	Homo sapiens	P63027	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	VAMP2	Homo sapiens	P63027	Y2H Array	25416956
Intra	STX4	Q12846	VAMP2	Homo sapiens	P63027	Validated Y2H	25416956
Intra	STX4	Q12846	GIMAP5	Homo sapiens	Q96F15	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	25416956
Intra	STX4	Q12846	GIMAP5	Homo sapiens	Q96F15	Y2H Array	25416956
Intra	STX4	Q12846	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	STX4	Q12846	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	STX4	Q12846	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	STX4	Q12846	STX5	Homo sapiens	Q13190	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	STX5	Homo sapiens	Q13190	Validated Y2H	25416956
Intra	STX4	Q12846	STX5	Homo sapiens	Q13190	Validated Y2H	32296183
Intra	STX4	Q12846	STX5	Homo sapiens	Q13190	Y2H Array	25416956
Intra	STX4	Q12846	VAMP3	Homo sapiens	Q15836	Anti Tag CoIP	25416956
Intra	STX4	Q12846	VAMP3	Homo sapiens	Q15836	Anti Bait CoIP	12130530
Intra	STX4	Q12846	VAMP3	Homo sapiens	Q15836	Y2H Pooling	16189514
Intra	STX4	Q12846	VAMP3	Homo sapiens	Q15836	Validated Y2H	32296183
Intra	STX4	Q12846	VAMP3	Homo sapiens	Q15836	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	VTI1B	Homo sapiens	Q9UEU0	Validated Y2H	25416956
Intra	STX4	Q12846	VTI1B	Homo sapiens	Q9UEU0	Validated Y2H	32296183
Intra	STX4	Q12846	VTI1B	Homo sapiens	Q9UEU0	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	STX8	Homo sapiens	Q9UNK0	Validated Y2H	25416956
Intra	STX4	Q12846	STX8	Homo sapiens	Q9UNK0	Validated Y2H	32296183
Intra	STX4	Q12846	STX8	Homo sapiens	Q9UNK0	Y2H Array	25416956
Intra	STX4	Q12846	USE1	Homo sapiens	Q9NZ43	Validated Y2H	32296183
Intra	STX4	Q12846	VAMP4	Homo sapiens	O75379	Validated Y2H	25416956
Intra	STX4	Q12846	VAMP4	Homo sapiens	O75379	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	VAMP4	Homo sapiens	O75379	Y2H Pooling	16189514
Intra	STX4	Q12846	BET1	Homo sapiens	O15155	Y2H Array	25416956
Intra	STX4	Q12846	NAPA	Homo sapiens	P54920	Y2H Pooling	16189514
Intra	STX4	Q12846	TRAF3IP3	Homo sapiens	Q9Y228	Validated Y2H	32296183
Intra	STX4	Q12846	CYBRD1	Homo sapiens	Q53TN4	Validated Y2H	25416956
Intra	STX4	Q12846	CYBRD1	Homo sapiens	Q53TN4	Y2H Array	25416956
Intra	STX4	Q12846	CYBRD1	Homo sapiens	Q53TN4	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	SEC22A	Homo sapiens	Q96IW7	Y2H Prey Pooling	25416956
Intra	STX4	Q12846	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Type 1 Diabetes Mellitus 10	Diabetes Mellitus, Insulin-Dependent, 10 IDDM10 Insulin-Dependent Diabetes Mellitus 10 Diabetes, Mellitus, Insulin-Dependent, Susceptibility To, 10 T1D10 Diabetes, Mellitus, Insulin-Dependent 10 Diabetes Mellitus, Insulin-Dependent, Type 10
Hemophagocytic Lymphohistiocytosis, Familial, 4	Familial Hemophagocytic Lymphohistiocytosis 4 FHL4 Hplh4 Hlh4 Lymphohistiocytosis, Hemophagocytic, Familial, Type 4
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13984	STX4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	STX4	VGNC	VGNC:99601
Felis catus	STX4	VGNC	VGNC:65814
Mus musculus	STX4	MGD	MGI:893577
Canis familiaris	STX4	VGNC	VGNC:46956
Rattus norvegicus	STX4	RGD	RGD:621019
Bos taurus	STX4	VGNC	VGNC:35440
Others	STX4	NCBI