2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. EGFR
  4. EGFR-IN-63

EGFR-IN-63 is an EGFR inhibition (IC50: 0.096 μM) and it has anticancer activity in MCF-7 cells (IC50: 2.49 μM).

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EGFR-IN-63 Chemical Structure

EGFR-IN-63 Chemical Structure

CAS No. : 2414635-72-4

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EGFR-IN-63 Related Antibodies

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Description

EGFR-IN-63 is an EGFR inhibition (IC50: 0.096 μM) and it has anticancer activity in MCF-7 cells (IC50: 2.49 μM).

In Vitro

EGFR- IN-63 (2-4 hours) has superior EGFR inhibition (IC50 = 0.096 μM) compared to Gefitinib (IC50 = 0.166 μM)and anticancer activity against MCF-7 cell line (IC50 = 2.49 μM) compared to Gefitinib (IC50 = 4.972 μM). EGFR- IN-63 leads to pre G1 apoptosis with cell growth arrest at G2/M phase in MCF-7 cells after 24 h, the percentage of DNA content (41.45 %) shows increase compared to the control cells (7.1 %). EGFR- IN-63 arrest cell growth at G2/M phase and induces its apoptotic effect. The percentage of the total apoptotic cells in MCF-7 cell line increases after treatment with EGFR- IN-63(24.19 %) relative to control cells (1.47 %)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR-IN-63 Related Antibodies

Cell Cytotoxicity Assay

Cell Line: A549, MCF-7,WI38, PC9 and HCC827 cell lines
Concentration: 10% of the culture medium volume
Incubation Time: 2 - 4 hours
Result: Displayed superior EGFR inhibitory、anticancer activity and low cytotoxicity.

Cell Cycle Analysis

Cell Line: MCF-7
Concentration: 0.01 μM
Incubation Time: 24 hour
Result: Led to pre G1 apoptosis with cell growth arrest at G2/M phase in MCF-7 cells.

Apoptosis Analysis

Cell Line: MCF-7
Concentration: 0.01 μM
Incubation Time: 24 hour
Result: Revealed cell growth arrest at G2/M phase and inducted apoptotic effect.
Molecular Weight

434.31

Formula

C20H12BrN5S
CAS No.
SMILES

BrC1=CC2=C(NC3=NC4=CC=CC=C4S3)N=C(C5=CC=CN=C5)N=C2C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR-IN-63 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR-IN-632414635-72-4EGFREpidermal growth factor receptorErbB-1HER1EGFR inhibitorquinazolineanticancerInhibitorinhibitorinhibit

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EGFR-IN-63
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