Artecanin
Artecanin is a SARS-CoV-2 main protease (Mpro) inhibitor with predicted high gastrointestinal absorption and oral bioavailability, and no predicted hepatotoxicity, carcinogenicity, mutagenicity or cytotoxicity. Artecanin interacts with His41 and Cys145, the key amino acid residues in the active site of Mpro, blocks the cleavage and maturation of viral precursor proteins, and forms a stable complex with Mpro. Artecanin blocks the invasion of SARS-CoV-2. Artecanin is applicable to the research of COVID-19.
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- No. CAS: 29431-84-3
- Fòrmula: C15H18O5
- Peso molecular:278.30
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
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| T-cell | IC50 |
3.7 μM
Compound: 5
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Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis
Immunosuppressant activity in human T lymphocytes assessed as inhibition of anti-human CD3 and anti-human CD28 monoclonal antibody-induced T lymphocyte proliferation incubated for 72 hrs by FACS analysis
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[PMID: 31181920] |
Artecanin exhibits favorable druglikeness properties (compliant with all standard rules, high gastrointestinal absorption) and has no predicted toxicities (hepatotoxicity, carcinogenicity, mutagenicity, cytotoxicity)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 29431-84-3
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Peso molecular 278.30
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Fòrmula C15H18O5
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SMILES
C[C@]1(O)[C@]23[C@](O2)([C@]4([C@@](C)([C@@]3([C@@]5([C@@](CC1)(C(=C)C(=O)O5)[H])[H])[H])O4)[H])[H]
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Artecanin Related Classifications
HY-127083 Related Classifications
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