Pak1 - p21 (RAC1) activated kinase 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29431

About Pak1

Primary_assembly 1: 152,111,188-152,226,383 forward strand.mRatBN7.2:CM026974.1

This gene has 4 transcripts (splice variants), 216 orthologues, 36 paralogues and is associated with 20 phenotypes. Biased expression in Brain (RPKM 564.9), Adrenal (RPKM 131.3) and 7 other tissues.

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; nervous system development; and positive regulation of cell migration. Located in several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pak1 Products (1)

mRNA Protein Name
NM_017198.2 NP_058894.1 serine/threonine-protein kinase PAK 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
11895474 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
15542607 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18054038 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
12237306 RGD
Biological Process GO Annotation Evidence Références Source
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
8702668 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
20395366 RGD
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
20395366 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
22082674 RGD
involved in neuron projection morphogenesis IMP
IMP: Inferred from mutant phenotype
9451000 RGD
involved in positive regulation of axon extension IMP
IMP: Inferred from mutant phenotype
23453953 RGD
involved in positive regulation of fibroblast migration IDA
IDA: Inferred from direct assay
18931661 RGD
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
25199455 RGD
involved in positive regulation of peptidyl-serine phosphorylation IMP
IMP: Inferred from mutant phenotype
23453953 RGD
involved in positive regulation of protein targeting to membrane IMP
IMP: Inferred from mutant phenotype
25199455 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
19901155 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
19901155 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
15542607 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12237306 RGD
involved in regulation of actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
18347024 RGD
involved in response to hypoxia IDA
IDA: Inferred from direct assay
9367856 RGD
Cellular Component GO Annotation Evidence Références Source
located in Z disc IDA
IDA: Inferred from direct assay
14670848 RGD
located in axon IDA
IDA: Inferred from direct assay
17687038 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17687038 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
14670848 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
19574218 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
14670848 RGD
located in ruffle IDA
IDA: Inferred from direct assay
19574218 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pak1 Protein Structure

PBD

PBD: pfam00786 (73 - 131)

STKc_PAK1

STKc_PAK1: cd06654 (247 - 542)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 544 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PAK 1

  • PAK-1

  • alpha-PAK

  • p21 (CDKN1A)-activated kinase 1

  • p21 protein (Cdc42/Rac)-activated kinase 1

  • p21-activated kinase 1

  • p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)

  • p68-PAK

  • protein kinase MUK2

Pak1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Pak1 P35465 Vim Mus musculus P20152
Protein Kinase Assay
11895474
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-12005 Fingolimod hydrochloride Activator 99.94% Yes
HY-15027 5-Aminosalicylic Acid Inhibitor 99.97% Unkown
HY-11063 Fingolimod Activator 99.97% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Phase
HY-110085 2,2′-Dihydroxy-6,6′-dinaphthyl disulfide Inhibitor 98.49% Phase 4
HY-13007 PF-3758309 Inhibitor 99.79% Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-15663 IPA-3 Inhibitor 99.39% Unkown
HY-15542A FRAX597 Inhibitor 99.36% Unkown
HY-15542B FRAX486 Inhibitor 98.10% Unkown
HY-19635 G-5555 Inhibitor 99.88% Unkown
HY-19538 FRAX1036 Inhibitor 98.88% Unkown
HY-120940 AZ13705339 Inhibitor 98.57% Unkown
HY-19635A G-5555 hydrochloride Inhibitor 98.26% Unkown
HY-131043 NVS-PAK1-C Inhibitor 99.2% Unkown
HY-120940A AZ13705339 hemihydrate Inhibitor 99.77% Unkown
HY-182357 PAK1-IN-3 Inhibitor / Unkown
HY-146681 PAK1-IN-1 Inhibitor / Unkown
HY-164534 SIK2/3-IN-2 Inhibitor / Unkown
HY-116917 G-9791 Inhibitor / Unkown
HY-146786 ZMF-10 Inhibitor / Unkown
HY-159897 PAK4-IN-5 Inhibitor / Unkown
HY-146783 ZINC194100678 Inhibitor / Unkown
HY-184145 AKT1-IN-13 Inhibitor / Unkown
HY-119216 AZ13711265 Inhibitor / Unkown
HY-13007B PF-3758309 dihydrochloride Inhibitor / Unkown
HY-13007A PF-3758309 hydrochloride Inhibitor / Unkown
HY-131265 Mesalamine impurity P Inhibitor / Unkown
HY-176539 PAK1-IN-2 Inhibitor / Unkown
HY-164374 AK963/40708899 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pak1 NCBI NCBI:5058