PAK1 - p21 (RAC1) activated kinase 1 Gene

Also Known as IDDMSSD; p65-PAK; PAKalpha; alpha-PAK

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5058

About PAK1

Cytogenetic location: 11q13.5-q14.1 Genomic coordinates (GRCh38): 11:77,322,017-77,530,009 (from NCBI)

This gene has 20 transcripts (splice variants), 217 orthologues, 35 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 55.5), thyroid (RPKM 19.6) and 23 other tissues.

Summary

This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to Cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many Cancer types, and particularly in breast Cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]

PAK1 Products (50)

mRNA	Protein	Name
NM_001376294.1	NP_001363223.1	serine/threonine-protein kinase PAK 1 isoform 8
NM_001376272.1	NP_001363201.1	serine/threonine-protein kinase PAK 1 isoform 3
NM_001376305.1	NP_001363234.1	serine/threonine-protein kinase PAK 1 isoform 13
NM_001376280.1	NP_001363209.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376271.1	NP_001363200.1	serine/threonine-protein kinase PAK 1 isoform 1
NM_001376286.1	NP_001363215.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376302.1	NP_001363231.1	serine/threonine-protein kinase PAK 1 isoform 11
NM_001376292.1	NP_001363221.1	serine/threonine-protein kinase PAK 1 isoform 7
NM_001376293.1	NP_001363222.1	serine/threonine-protein kinase PAK 1 isoform 7
XM_024448558.2	XP_024304326.1	serine/threonine-protein kinase PAK 1 isoform X3
XM_047427053.1	XP_047283009.1	serine/threonine-protein kinase PAK 1 isoform X4
XM_047427054.1	XP_047283010.1	serine/threonine-protein kinase PAK 1 isoform X4
XM_047427052.1	XP_047283008.1	serine/threonine-protein kinase PAK 1 isoform X3
NR_164798.1
XM_047427046.1	XP_047283002.1	serine/threonine-protein kinase PAK 1 isoform X1
NM_001376281.1	NP_001363210.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376282.1	NP_001363211.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376285.1	NP_001363214.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376269.1	NP_001363198.1	serine/threonine-protein kinase PAK 1 isoform 1
XM_047427050.1	XP_047283006.1	serine/threonine-protein kinase PAK 1 isoform X3
NM_001376284.1	NP_001363213.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376295.1	NP_001363224.1	serine/threonine-protein kinase PAK 1 isoform 9
NM_001376270.1	NP_001363199.1	serine/threonine-protein kinase PAK 1 isoform 1
NM_001376303.1	NP_001363232.1	serine/threonine-protein kinase PAK 1 isoform 12
XM_024448557.2	XP_024304325.1	serine/threonine-protein kinase PAK 1 isoform X3
NM_001376274.1	NP_001363203.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376277.1	NP_001363206.1	serine/threonine-protein kinase PAK 1 isoform 2
XM_024448560.2	XP_024304328.1	serine/threonine-protein kinase PAK 1 isoform X4
XM_024448559.2	XP_024304327.1	serine/threonine-protein kinase PAK 1 isoform X3
XM_047427051.1	XP_047283007.1	serine/threonine-protein kinase PAK 1 isoform X3
NM_001376268.1	NP_001363197.1	serine/threonine-protein kinase PAK 1 isoform 1
NM_001376289.1	NP_001363218.1	serine/threonine-protein kinase PAK 1 isoform 5
NM_001376273.1	NP_001363202.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376290.1	NP_001363219.1	serine/threonine-protein kinase PAK 1 isoform 6
XM_047427049.1	XP_047283005.1	serine/threonine-protein kinase PAK 1 isoform X3
XM_047427047.1	XP_047283003.1	serine/threonine-protein kinase PAK 1 isoform X2
NM_001128620.2	NP_001122092.1	serine/threonine-protein kinase PAK 1 isoform 1
NM_001376279.1	NP_001363208.1	serine/threonine-protein kinase PAK 1 isoform 2
XM_047427048.1	XP_047283004.1	serine/threonine-protein kinase PAK 1 isoform X3
NM_001376291.1	NP_001363220.1	serine/threonine-protein kinase PAK 1 isoform 6
NM_001376288.1	NP_001363217.1	serine/threonine-protein kinase PAK 1 isoform 4
NM_001376275.1	NP_001363204.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376304.1	NP_001363233.1	serine/threonine-protein kinase PAK 1 isoform 13
NM_001376283.1	NP_001363212.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376276.1	NP_001363205.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376301.1	NP_001363230.1	serine/threonine-protein kinase PAK 1 isoform 10
NM_002576.5	NP_002567.3	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376287.1	NP_001363216.1	serine/threonine-protein kinase PAK 1 isoform 2
NM_001376278.1	NP_001363207.1	serine/threonine-protein kinase PAK 1 isoform 2
NR_164797.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables collagen binding	IPI IPI: Inferred from physical interaction	12189148	GOA
enables gamma-tubulin binding	IDA IDA: Inferred from direct assay	27012601	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17389360	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10026169	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	8805275	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	10559936	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	16278681	GOA
contributes to small GTPase binding	IPI IPI: Inferred from physical interaction	11950598	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	23260667	GOA
NOT involved in MAPK cascade	IDA IDA: Inferred from direct assay	8805275	GOA
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	9395435	GOA
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27917469	GOA
involved in actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	16278681	GOA
involved in branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	20457839	GOA
acts upstream of or within cell migration	IMP IMP: Inferred from mutant phenotype	27917469	GOA
involved in chromatin remodeling	IDA IDA: Inferred from direct assay	23260667	GOA
involved in hepatocyte growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	25198505	GOA
involved in negative regulation of cell proliferation involved in contact inhibition	IMP IMP: Inferred from mutant phenotype	12912914	GOA
involved in phosphorylation	IDA IDA: Inferred from direct assay	27012601	GOA
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	8805275	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	25766321	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	23333386	GOA
involved in positive regulation of intracellular estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	16278681	GOA
involved in positive regulation of microtubule nucleation	IMP IMP: Inferred from mutant phenotype	27012601	GOA
involved in positive regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	25198505	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	19667065	GOA
involved in positive regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	23633677	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	11864573	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	8805275	GOA
involved in protein localization to cytoplasmic stress granule	IDA IDA: Inferred from direct assay	20417602	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9852149	GOA
involved in wound healing	IMP IMP: Inferred from mutant phenotype	12912914	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IDA IDA: Inferred from direct assay	9395435	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	12912914	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16278681	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	23260667	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16278681	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	11864573	GOA
located in ruffle	IDA IDA: Inferred from direct assay	12912914	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK1 Protein Structure

PBD

Pkinase

0
100
200
300
400
500
545 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PAK 1	STE20 homolog, yeast p21 protein (Cdc42/Rac)-activated kinase 1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)

PAK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PAK1	Q13153	TTC12	Homo sapiens	Q9H892-2	Y2H Pooling	32814053
Intra	PAK1	Q13153	TTC12	Homo sapiens	Q9H892-2	Validated Y2H	32814053
Intra	PAK1	Q13153	TTC12	Homo sapiens	Q9H892-2	Y2H Array	32814053
Intra	PAK1	Q13153	GIT2	Homo sapiens	Q14161	Anti Tag CoIP	35271311
Intra	PAK1	Q13153	GIT2	Homo sapiens	Q14161	Anti Tag CoIP	31980649
Intra	PAK1	Q13153	ZNF444	Homo sapiens	Q8N0Y2-2	Validated Y2H	32814053
Intra	PAK1	Q13153	ZNF444	Homo sapiens	Q8N0Y2-2	Y2H Pooling	32814053
Intra	PAK1	Q13153	ZNF444	Homo sapiens	Q8N0Y2-2	Y2H Array	32814053
Intra	PAK1	Q13153	GRB10	Homo sapiens	Q13322-4	Y2H Pooling	32814053
Intra	PAK1	Q13153	GRB10	Homo sapiens	Q13322-4	Validated Y2H	32814053
Intra	PAK1	Q13153	GRB10	Homo sapiens	Q13322-4	Y2H Array	32814053
Intra	PAK1	Q13153	CDK11B	Homo sapiens	P21127	Y2H	12624090
Intra	PAK1	Q13153	CDK11B	Homo sapiens	P21127	Anti Tag CoIP	12624090
Intra	PAK1	Q13153	CDK11B	Homo sapiens	P21127	Pull Down	12624090
Intra	PAK1	Q13153	CDK11B	Homo sapiens	P21127	Anti Tag CoIP	16413544
Intra	PAK1	Q13153	ARHGEF6	Homo sapiens	Q15052	TAP	23455922
Intra	PAK1	Q13153	ARHGEF6	Homo sapiens	Q15052	Anti Tag CoIP	35271311
Intra	PAK1	Q13153	ARHGEF6	Homo sapiens	Q15052	Anti Tag CoIP	31980649
Intra	PAK1	Q13153	TIMM17B	Homo sapiens	O60830	Y2H Array	32814053
Intra	PAK1	Q13153	TIMM17B	Homo sapiens	O60830	Y2H Pooling	32814053
Intra	PAK1	Q13153	TIMM17B	Homo sapiens	O60830	Validated Y2H	32814053
Intra	PAK1	Q13153	ZHX1-C8orf76	Homo sapiens	Q96EF9	Y2H Array	32814053
Intra	PAK1	Q13153	ZHX1-C8orf76	Homo sapiens	Q96EF9	Y2H Pooling	32814053
Intra	PAK1	Q13153	ZHX1-C8orf76	Homo sapiens	Q96EF9	Validated Y2H	32814053
Intra	PAK1	Q13153	ADD1	Homo sapiens	P35611	Validated Y2H	32814053
Intra	PAK1	Q13153	ADD1	Homo sapiens	P35611	Y2H Array	32814053
Intra	PAK1	Q13153	ADD1	Homo sapiens	P35611	Y2H Pooling	32814053
Intra	PAK1	Q13153	ACP2	Homo sapiens	P11117	Validated Y2H	32814053
Intra	PAK1	Q13153	ACP2	Homo sapiens	P11117	Y2H Array	32814053
Intra	PAK1	Q13153	ACP2	Homo sapiens	P11117	Y2H Pooling	32814053
Intra	PAK1	Q13153	MAPK11	Homo sapiens	Q15759	Y2H Pooling	32814053
Intra	PAK1	Q13153	MAPK11	Homo sapiens	Q15759	Validated Y2H	32814053
Intra	PAK1	Q13153	MAPK11	Homo sapiens	Q15759	Y2H Array	32814053
Intra	PAK1	Q13153	DYNLL1	Homo sapiens	P63167	Validated Y2H	32814053
Intra	PAK1	Q13153	DYNLL1	Homo sapiens	P63167	Y2H Pooling	32814053
Intra	PAK1	Q13153	DYNLL1	Homo sapiens	P63167	Y2H Array	32814053
Intra	PAK1	Q13153	DYNLL1	Homo sapiens	P63167	Y2H	21988832
Intra	PAK1	Q13153	b3kx85_human	Homo sapiens	B3KX85	Y2H	16278681
Intra	PAK1	Q13153	RIT1	Homo sapiens	Q92963	Confocal	29734338
Intra	PAK1	Q13153	RIT1	Homo sapiens	Q92963	Anti Bait CoIP	29734338
Intra	PAK1	Q13153	TCP10L	Homo sapiens	Q8TDR4	Y2H Array	32814053
Intra	PAK1	Q13153	TCP10L	Homo sapiens	Q8TDR4	Y2H Pooling	32814053
Intra	PAK1	Q13153	TCP10L	Homo sapiens	Q8TDR4	Validated Y2H	32814053
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	21167153
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	21454543
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	26175416
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	19270716
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	25843002
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	FRET	11030651
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	24172987
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	12879077
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	24625804
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	16492808
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	24792722
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	17245428
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Anti Tag CoIP	20810653
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000	Pull Down	21029865
Cross	PAK1	Q13153	Rac1	Mus musculus	P63001	Pull Down	19893577
Cross	PAK1	Q13153	Rac1	Mus musculus	P63001	Pull Down	18854161
Cross	PAK1	Q13153	Rac1	Mus musculus	P63001	Pull Down	18325335
Intra	PAK1	Q13153	LIMK1	Homo sapiens	P53667	Protein Kinase Assay	10559936
Intra	PAK1	Q13153	LIMK1	Homo sapiens	P53667	Anti Bait CoIP	10559936
Intra	PAK1	Q13153	LIMK1	Homo sapiens	P53667	IF	10559936
Intra	PAK1	Q13153	GIT1	Homo sapiens	Q9Y2X7	Anti Tag CoIP	31980649
Intra	PAK1	Q13153	GIT1	Homo sapiens	Q9Y2X7	TAP	23455922
Intra	PAK1	Q13153	GIT1	Homo sapiens	Q9Y2X7	Anti Tag CoIP	25852190
Intra	PAK1	Q13153	NOTCH1	Homo sapiens	P46531	Anti Bait CoIP	33189893
Intra	PAK1	Q13153	NCK2	Homo sapiens	O43639	Anti Tag CoIP	31980649
Intra	PAK1	Q13153	NCK2	Homo sapiens	O43639	Y2H Array	31515488
Intra	PAK1	Q13153	NCK2	Homo sapiens	O43639	Anti Tag CoIP	35271311
Intra	PAK1	Q13153	NCK2	Homo sapiens	O43639	Validated Y2H	25416956
Intra	PAK1	Q13153	NCK2	Homo sapiens	O43639	Y2H Array	25416956
Intra	PAK1	Q13153	NCK2	Homo sapiens	O43639	TAP	23455922
Intra	PAK1	Q13153	STX11	Homo sapiens	O75558	Validated Y2H	32814053
Intra	PAK1	Q13153	STX11	Homo sapiens	O75558	Y2H Array	32814053
Intra	PAK1	Q13153	STX11	Homo sapiens	O75558	Y2H Pooling	32814053
Intra	PAK1	Q13153	KLHL20	Homo sapiens	Q9Y2M5	Y2H Pooling	32814053
Intra	PAK1	Q13153	KLHL20	Homo sapiens	Q9Y2M5	Validated Y2H	32814053
Intra	PAK1	Q13153	KLHL20	Homo sapiens	Q9Y2M5	Y2H Array	32814053
Intra	PAK1	Q13153	ARHGEF7	Homo sapiens	Q14155	BRET	29997244
Intra	PAK1	Q13153	ARHGEF7	Homo sapiens	Q14155	Lumier	32814053
Intra	PAK1	Q13153	ARHGEF7	Homo sapiens	Q14155	Fluorescence Spectr	16101281
Intra	PAK1	Q13153	ARHGEF7	Homo sapiens	Q14155	Anti Bait CoIP	16628223
Intra	PAK1	Q13153	ARHGEF7	Homo sapiens	Q14155	TAP	23455922
Intra	PAK1	Q13153	ARHGEF7	Homo sapiens	Q14155	Pull Down	16492808
Intra	PAK1	Q13153	ARHGEF7	Homo sapiens	Q14155	Anti Tag CoIP	31980649
Intra	PAK1	Q13153	ARHGEF7	Homo sapiens	Q14155	Anti Bait CoIP	16407834
Intra	PAK1	Q13153	RAC1	Homo sapiens	P63000-1	Pull Down	25150978
Intra	PAK1	Q13153	CDC42	Homo sapiens	P60953	Pull Down	12879077
Intra	PAK1	Q13153	CDC42	Homo sapiens	P60953	Pull Down	7744004
Intra	PAK1	Q13153	CDC42	Homo sapiens	P60953	Anti Tag CoIP	12606577
Intra	PAK1	Q13153	CDC42	Homo sapiens	P60953	Imaging	7744004
Intra	PAK1	Q13153	CDC42	Homo sapiens	P60953	Pull Down	21167153
Intra	PAK1	Q13153	CDC42	Homo sapiens	P60953	Pull Down	21029865
Intra	PAK1	Q13153	CDC42	Homo sapiens	P60953	Pull Down	23175184
Intra	PAK1	Q13153	CDC42	Homo sapiens	P60953	TAP	23455922
Cross	PAK1	Q13153	Cdc42	Mus musculus	P60766	Pull Down	18325335
Cross	PAK1	Q13153	Cdc42	Mus musculus	P60766	Pull Down	19893577
Intra	PAK1	Q13153	OTX2	Homo sapiens	P32243-2	Validated Y2H	32814053
Intra	PAK1	Q13153	OTX2	Homo sapiens	P32243-2	Y2H Pooling	32814053
Intra	PAK1	Q13153	OTX2	Homo sapiens	P32243-2	Y2H Array	32814053
Intra	PAK1	Q13153	SEMA4G	Homo sapiens	Q9NTN9-3	Validated Y2H	32814053
Intra	PAK1	Q13153	SEMA4G	Homo sapiens	Q9NTN9-3	Y2H Array	32814053
Intra	PAK1	Q13153	SEMA4G	Homo sapiens	Q9NTN9-3	Y2H Pooling	32814053
Intra	PAK1	Q13153	TCAP	Homo sapiens	O15273	Y2H Array	32814053
Intra	PAK1	Q13153	TCAP	Homo sapiens	O15273	Validated Y2H	32814053
Intra	PAK1	Q13153	TCAP	Homo sapiens	O15273	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PAK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71530	PAK1 Protein, Human (His-SUMO)	Q13153-1 (M1-H545)	≥ 90%, as determined by reducing SDS-PAGE.

PAK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81618	PAK1 Antibody (YA1363)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat
HY-P86446	PAK1 Antibody (YA6138)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Granulomatous Disease, Chronic, Autosomal Recessive, 2	Chronic Granulomatous Disease Due To Deficiency Of Ncf-2 CGD2 Ncf2 Deficiency P67-Phox Deficiency Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type Ii Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 2 Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type Ii Cgd, Autosomal Recessive Cytochrome B-Positive, Type Ii Granulomatous Disease, Chronic, Due To Ncf2 Deficiency Neutrophil Cytosol Factor 2 Deficiency Chronic Granulomatous Disease 2, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 2 Cdg2 Deficiency Of Ncf2 Deficiency Of P67-Phox Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type Ii Deficiency Of Neutrophil Cytosol Factor 2 Avellino Corneal Dystrophy
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Neurofibromatosis	Neurofibromatoses Acoustic Neurofibromatosis Central Neurofibromatosis Peripheral Neurofibromatosis Recklinghausen'S Neurofibromatosis Von Reklinghausen Disease Neurofibromatosis Type 1
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gastric Cancer	Stomach Cancer Stomach Carcinoma Gastric Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Intellectual Developmental Disorder With Macrocephaly, Seizures, And Speech Delay	IDDMSSD
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Prolapse Of Urethra	Urethrocele
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12005	Fingolimod hydrochloride	Activator	99.94%	Yes
HY-15027	5-Aminosalicylic Acid	Inhibitor	99.97%	Unkown
HY-11063	Fingolimod	Activator	99.97%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-110085	2,2′-Dihydroxy-6,6′-dinaphthyl disulfide	Inhibitor	98.49%	Phase 4
HY-13007	PF-3758309	Inhibitor	99.79%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15663	IPA-3	Inhibitor	99.39%	Unkown
HY-15542A	FRAX597	Inhibitor	99.36%	Unkown
HY-15542B	FRAX486	Inhibitor	98.10%	Unkown
HY-19635	G-5555	Inhibitor	99.88%	Unkown
HY-19538	FRAX1036	Inhibitor	98.88%	Unkown
HY-120940	AZ13705339	Inhibitor	98.57%	Unkown
HY-19635A	G-5555 hydrochloride	Inhibitor	98.26%	Unkown
HY-131043	NVS-PAK1-C	Inhibitor	99.2%	Unkown
HY-120940A	AZ13705339 hemihydrate	Inhibitor	99.77%	Unkown
HY-182357	PAK1-IN-3	Inhibitor	/	Unkown
HY-146681	PAK1-IN-1	Inhibitor	/	Unkown
HY-164534	SIK2/3-IN-2	Inhibitor	/	Unkown
HY-116917	G-9791	Inhibitor	/	Unkown
HY-146786	ZMF-10	Inhibitor	/	Unkown
HY-159897	PAK4-IN-5	Inhibitor	/	Unkown
HY-146783	ZINC194100678	Inhibitor	/	Unkown
HY-184145	AKT1-IN-13	Inhibitor	/	Unkown
HY-119216	AZ13711265	Inhibitor	/	Unkown
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Unkown
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Unkown
HY-131265	Mesalamine impurity P	Inhibitor	/	Unkown
HY-176539	PAK1-IN-2	Inhibitor	/	Unkown
HY-164374	AK963/40708899	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PAK1	MGD	MGI:1339975
Canis familiaris	PAK1	VGNC	VGNC:52285
Felis catus	PAK1	VGNC	VGNC:81962
Bos taurus	PAK1	VGNC	VGNC:53657
Rattus norvegicus	PAK1	RGD	RGD:3250
Macaca mulatta	PAK1	VGNC	VGNC:101373
Others	PAK1	NCBI