Nrf2/HO-1 activator 2
Nrf2/HO-1 activator 2 (compound 13m), difluoro-substituted derivative, is a potent Nrf2/HO-1 activator. Nrf2/HO-1 activator 2 has neuroprotective and antioxidant effects through the Nrf2/HO-1 pathway mediated by phosphorylation of ERK1/2, JNK, or Akt in PC12 cells. Nrf2/HO-1 activator 2 can be used in the research of Parkinson's disease (PD).
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- CAS No.: 2883506-31-6
- Formule: C20H16F2O5
- Masse moléculaire:374.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
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| PC-12 | IC50 |
4.2 μM
Compound: 13m
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Cytotoxicity in rat PC-12 cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity in rat PC-12 cells assessed as cell viability incubated for 24 hrs by MTT assay
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[PMID: 36029560] |
| PC-12 | IC50 |
4.7 μM
Compound: 13m
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Neurotoxicity in rotenone induced at rat PC-12 cells assessed as cell viability pretreated with compound for 4 hrs followed by rotenone addition measured after 24 hrs by MTT assay
Neurotoxicity in rotenone induced at rat PC-12 cells assessed as cell viability pretreated with compound for 4 hrs followed by rotenone addition measured after 24 hrs by MTT assay
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[PMID: 36029560] |
Nrf2/HO-1 activator 2 (compound 13m; 0.1-30 µM; 24 h) has protection to PC12 cells against toxicity and inhibits 6-OHDA- and Rotenone (HY-B1756)- induced cell death[1].
Nrf2/HO-1 activator 2 (1-100 µM; 11 h) inhibits 6-OHDA- or rotenone-induced production of reactive oxygen species and partially attenuates lipid peroxidation in rat brain homogenates. Nrf2/HO-1 activator 2 inhibits the production of lipid peroxide in rat brain homogenates by 28.8% at 100 μM[1].
Nrf2/HO-1 activator 2 (1-100 µM; 11 h) up-regulates heme oxygenase-1 (HO-1) and Nrf2 expression[1].
Nrf2/HO-1 activator 2 (10 µM; 2-3 h; PC12 cells) activator 2 activates Nrf2/HO-1 signaling by phosphorylated ERK1/2, JNK, and Akt[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:3, 5, 7, 10 and 30 µM, 6-OHDA (50 µM); 0.1, 0.3, 1, 3, 10, and 30 µM, Rotenone (1 µM)
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Incubation Time:24 hours
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Result:Exhibited neuroprotective effects on 6-OHDA-induced toxicity in dose-dependent manners.
Rescued cells from rotenone-induced damage, with increased levels of cell viability up to 79.9% at 30 μM.
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Cell Line:PC12 cells
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Concentration:0, 1, 3, 10, and 30 µM
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Incubation Time:24 hours
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Result:Upregulated HO-1 levels in a dose-dependent manner, with 1.5- and 2-fold increases at 30 μM concentrations, respectively.
Enhanced the nuclear translocation of Nrf2 in PC12 cells after 3 h at 10 µM.
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Cell Line:PC12 cells
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Concentration:10 µM
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Incubation Time:2-3 hours
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Result:Induced the phosphorylation of ERK1/2, JNK, and Akt.
Chemical Information
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CAS No. 2883506-31-6
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Masse moléculaire 374.33
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Formule C20H16F2O5
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SMILES
O=C1C(C2=CC=C(F)C=C2F)=COC3=C1C4=C(CC(O)C(C)(C)O4)C(O)=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nrf2/HO-1 activator 2 Related Classifications
HY-151431 Related Classifications
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