EDP-420
EDP-420 (EP-013420; S-013420) is an orally active antibacterial agent. EDP-420 inhibits the Mycobacterium avium complex (MAC) in macrophages. EDP-420 reduces bacterial counts in a mouse model of macrolide infection. EDP-420 inhibits pneumococcal activity in a rabbit model of meningitis. EDP-420 can be used in research on inflammatory infectious diseases such as meningitis.
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- No. CAS: 736992-12-4
- Fòrmula: C43H64N6O11
- Peso molecular:841.00
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
Ensayo clínico
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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No. CAS 736992-12-4
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Peso molecular 841.00
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Fòrmula C43H64N6O11
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SMILES
C[C@]12[C@@H]([C@H](C([C@H](C(O[C@@H]([C@@](O)([C@@](OC/C(CO2)=N\OCC3=CN=C(N4C=CC=N4)C=C3)([H])[C@H](/C([C@@H](C1)C)=N/C(C)=O)C)C)CC)=O)C)=O)C)O[C@H]5[C@@H]([C@H](C[C@H](O5)C)N(C)C)O
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Synonyms
EP-013420; S-013420
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Bermudez LE, et al. EDP-420, a bicyclolide (bridged bicyclic macrolide), is active against Mycobacterium avium. Antimicrob Agents Chemother. 2007 May;51(5):1666-70. [Content Brief]
[2]. Stucki A, et al. Effects of EDP-420 on penicillin-resistant and quinolone- and penicillin-resistant pneumococci in the rabbit meningitis model. J Antimicrob Chemother. 2008 Mar;61(3):665-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EDP-420 Related Classifications
HY-106422 Related Classifications
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