GW559090
GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd of 0.19 nM for α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC50 values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC50 = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye.
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- No. CAS: 278598-52-0
- Fòrmula: C31H40N4O8
- Peso molecular:596.67
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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α4β1 0.19 nM (Kd) |
Chemical Information
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No. CAS 278598-52-0
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Peso molecular 596.67
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Fòrmula C31H40N4O8
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SMILES
O=C(O)[C@H](CC1=CC=C(OC(N2CCC(C(N)=O)CC2)=O)C=C1)NC([C@H](CC(C)C)NC(COC3=CC=CC=C3C)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GW559090 Related Classifications
HY-171216 Related Classifications
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