278598-52-0
Chemical Structure
GW559090
- CAS. Nr.: 278598-52-0
- Formula:C31H40N4O8
- Molecular Weight:596.67
InChIKey: RZMCXMNNXGCFQG-DQEYMECFSA-N
SMILES: O=C(O)[C@H](CC1=CC=C(OC(N2CCC(C(N)=O)CC2)=O)C=C1)NC([C@H](CC(C)C)NC(COC3=CC=CC=C3C)=O)=O
Biological Activity: GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd of 0.19 nM for α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC50 values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC50 = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye[1].
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GW559090 | GW559090 is a selective, competitive, and high-affinity α4 integrin antagonist with a Kd of 0.19 nM for α4β1. GW559090 can effectively block the binding of α4β1 to vascular cell adhesion molecule 1 (VCAM-1) and fibronectin with IC50 values of 7.72 and 8.04 nM. GW559090 also inhibits the interaction between α4β7 and mucosal addressin cell adhesion molecule 1 (MAdCAM-1) (IC50 = 23 nM). GW559090 can inhibit inflammatory infiltration in the eyes, repair the corneal barrier and restore the function of goblet cells. GW559090 can be used for research of Sjögren's syndrome associated dry eye. | |||||||||||||||||||||
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Keywords
