SJF-1521
Based on 1 Customer Validation
SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 is capable of inducing EGFR degradation in OVCAR8 cells. SJF-1521 can be used for tumor research.
(Pink: EGFR ligand (HY-177379); Blue: VHL ligand (HY-125845); Black: linker (HY-128804)).
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.65%
- No. CAS: 2230821-40-4
- Fòrmula: C57H61ClFN7O9S
- Peso molecular:1074.65
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Ver todos los productos específicos de isoformas PROTACs
MoreVer todos los productos específicos de isoformas EGFR
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Actividad biológica
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VHL |
SJF-1521 (25 nM-10 μM; 24 h) selectively degrades EGFR in OVCAR8 cells, while it has no effect on HER2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:OVCAR8 cells
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Concentration:25 nM, 100 nM, 250 nM, 1 μM, 2.5 μM, 10 μM
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Incubation Time:24 h
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Result:Significantly reduced the levels of EGFR, and did not affect the levels of HER2.
Chemical Information
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No. CAS 2230821-40-4
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Appearance Solid
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Peso molecular 1074.65
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Fòrmula C57H61ClFN7O9S
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Color Light green to yellow
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SMILES
O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOC(C=C4)=CC=C4C5=CC(C(NC6=CC(Cl)=C(C=C6)OCC7=CC(F)=CC=C7)=NC=N8)=C8C=C5)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : ≥ 200 mg/mL (186.11 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9305 mL | 4.6527 mL | 9.3054 mL | 23.2634 mL |
| 5 mM | 0.1861 mL | 0.9305 mL | 1.8611 mL | 4.6527 mL | |
| 10 mM | 0.0931 mL | 0.4653 mL | 0.9305 mL | 2.3263 mL | |
| 15 mM | 0.0620 mL | 0.3102 mL | 0.6204 mL | 1.5509 mL | |
| 20 mM | 0.0465 mL | 0.2326 mL | 0.4653 mL | 1.1632 mL | |
| 25 mM | 0.0372 mL | 0.1861 mL | 0.3722 mL | 0.9305 mL | |
| 30 mM | 0.0310 mL | 0.1551 mL | 0.3102 mL | 0.7754 mL | |
| 40 mM | 0.0233 mL | 0.1163 mL | 0.2326 mL | 0.5816 mL | |
| 50 mM | 0.0186 mL | 0.0931 mL | 0.1861 mL | 0.4653 mL | |
| 60 mM | 0.0155 mL | 0.0775 mL | 0.1551 mL | 0.3877 mL | |
| 80 mM | 0.0116 mL | 0.0582 mL | 0.1163 mL | 0.2908 mL | |
| 100 mM | 0.0093 mL | 0.0465 mL | 0.0931 mL | 0.2326 mL |
SJF-1521 Related Classifications
HY-131865 Related Classifications
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