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Referencia número: HY-124535

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TGX-115

Revisión del cliente

Based on 1 Customer Validation

TGX-115 is a p110β/p110δ-selective, PI3-K inhibitor. TGX-115 blocks p110β-mediated Akt phosphorylation induced by lysophosphatidic acid (LPA) in L6 myotubes, reduces insulin-stimulated PI(3,4)P2 and PIP3 levels in 3T3-L1 adipocytes. TGX-115 can be used for the study of diabetes mellitus.

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Pureza: 99.31%
No. CAS: 351071-62-0
Fòrmula: C₂₀H₂₀N₂O₃
Peso molecular:336.38

Almacenamiento:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

TGX-115 Chemical Structure

No. CAS: 351071-62-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Actividad biológica

Descripciòn

IC₅₀ & Target^[1][2]

p110β

p110δ

Ver todos los productos específicos de isoformas PI3K :

In Vitro

TGX-115 (0.1-10 μM, 6 h) blocks Akt (Ser473) phosphorylation but exerts no dose-dependent effect on Erk (Thr202/204) phosphorylation in U373MG glioma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TGX-115 (10 mg/kg, i.p., single dose) has no effect on insulin-induced blood glucose reduction in 4-month-old FVB/N female mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 351071-62-0
Appearance Solid
Peso molecular 336.38
Fòrmula C₂₀H₂₀N₂O₃
Color White to off-white
SMILES

O=C1C=C(N2CCOCC2)NC3=C1C=CC=C3OC4=C(C)C=CC=C4
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (274 KB)
SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Fan QW, et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell. 2006 May;9(5):341-9. [Content Brief]

[2]. Knight ZA, et al. A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. Cell. 2006 May 19;125(4):733-47. [Content Brief]

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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TGX-115

MCE Bioactive Compound Library

Ver todos los productos específicos de isoformas PI3K

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

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TGX-115 Related Classifications

HY-124535 Related Classifications