Nsun5 - NOL1/NOP2/Sun domain family, member 5 Gene

Also Known as Nol1r; Wbscr20; Wbscr20a; 9830109N13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 100609

Summary

Enables rRNA (cytosine-C5-)-methyltransferase activity. Involved in several processes, including central nervous system development; rRNA base methylation; and regulation of myelination. Predicted to be located in nucleoplasm. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Apr 2022]

Nsun5 Products (2)

mRNA Protein Name
NM_001359617.1 NP_001346546.1 28S rRNA (cytosine-C(5))-methyltransferase isoform 2
NM_145414.2 NP_663389.2 28S rRNA (cytosine-C(5))-methyltransferase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables rRNA (cytosine-C5-)-methyltransferase activity IDA
IDA: Inferred from direct assay
31722427 MGI
Biological Process GO Annotation Evidence References Source
involved in cerebral cortex development IMP
IMP: Inferred from mutant phenotype
31462248 MGI
involved in cognition IMP
IMP: Inferred from mutant phenotype
30485550 MGI
involved in corpus callosum development IMP
IMP: Inferred from mutant phenotype
31174389 MGI
involved in oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
30485550 MGI
involved in rRNA base methylation IDA
IDA: Inferred from direct assay
31722427 MGI
involved in regulation of myelination IMP
IMP: Inferred from mutant phenotype
31174389 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

28S rRNA (cytosine-C(5))-methyltransferase

  • Williams Beuren syndrome chromosome region 20A homolog

  • Williams-Beuren syndrome critical region protein 20

  • probable 28S rRNA (cytosine-C(5))-methyltransferase

  • putative methyltransferase NSUN5

  • williams-Beuren syndrome chromosomal region 20A protein hom

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09604 NSUN5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22693 Nsun5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29207 Nsun5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nsun5 NCBI NCBI:55695