Cdc42bpa - CDC42 binding protein kinase alpha Gene

Also Known as Mrck; Pk428

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 114116

Summary

Enables several functions, including ATP binding activity; identical protein binding activity; and magnesium ion binding activity. Involved in several processes, including actin Cytoskeleton organization; protein phosphorylation; and regulation of small GTPase mediated signal transduction. Located in actomyosin; cell leading edge; and cell-cell junction. Orthologous to human CDC42BPA (CDC42 binding protein kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Cdc42bpa Products (1)

mRNA	Protein	Name
NM_053657.2	NP_446109.2	serine/threonine-protein kinase MRCK alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	9418861	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	9418861	RGD
enables magnesium ion binding	IDA IDA: Inferred from direct assay	9418861	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18854160	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	9418861	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	9418861	RGD
involved in actomyosin structure organization	IMP IMP: Inferred from mutant phenotype	18854160	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18854160	RGD
involved in cytoskeleton organization	IDA IDA: Inferred from direct assay	9418861	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	9418861	RGD
involved in regulation of small GTPase mediated signal transduction	IDA IDA: Inferred from direct assay	9418861	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in actomyosin	IDA IDA: Inferred from direct assay	18854160	RGD
located in cell leading edge	IDA IDA: Inferred from direct assay	9418861	RGD
located in cell-cell junction	IDA IDA: Inferred from direct assay	9418861	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine/threonine-protein kinase MRCK alpha	MRCK alpha Ser-Thr protein kinase related to the myotonic dystrophy protein kinase myotonic dystrophy kinase-related CDC42-binding kinase alpha myotonic dystrophy protein kinase-like alpha mytonic dystrophy kinase-related Cdc42-binding kinase

Cdc42bpa Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Cdc42bpa	O54874	Lurap1	Rattus norvegicus	D4A8G3	Anti Bait CoIP	18854160
Intra	Cdc42bpa	O54874	Lurap1	Rattus norvegicus	D4A8G3	Pull Down	18854160
Intra	Cdc42bpa	O54874	Lurap1	Rattus norvegicus	D4A8G3	Anti Tag CoIP	18854160
Intra	Cdc42bpa	O54874	Cdc42bpb	Rattus norvegicus	Q7TT49	Anti Bait CoIP	18854160
Intra	Cdc42bpa	O54874	Limk1	Rattus norvegicus	P53669	Protein Kinase Assay	11340065
Intra	Cdc42bpa	O54874	PPP1R12A	Homo sapiens	O14974	Protein Kinase Assay	21457715
Intra	Cdc42bpa	O54874	Cdc42bpa	Rattus norvegicus	O54874	GMS	11283256
Intra	Cdc42bpa	O54874	Limk2	Rattus norvegicus	P53670	Protein Kinase Assay	11340065
Intra	Cdc42bpa	O54874	MYO18A	Homo sapiens	Q92614	Anti Tag CoIP	18854160

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02301	CDC42BPA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cdc42bpa	NCBI	NCBI:8476