CDC42BPA - CDC42 binding protein kinase alpha Gene

Also Known as MRCK; MRCKA; PK428

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8476

About CDC42BPA

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:226,989,858-227,318,492 (from NCBI)

This gene has 15 transcripts (splice variants), 234 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 11.8), kidney (RPKM 9.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018]

CDC42BPA Products (7)

mRNA Protein Name
NM_001366010.2 NP_001352939.1 serine/threonine-protein kinase MRCK alpha isoform D
NM_001366011.1 NP_001352940.1 serine/threonine-protein kinase MRCK alpha isoform E
NM_001366019.2 NP_001352948.1 serine/threonine-protein kinase MRCK alpha isoform C
NM_001387550.1 NP_001374479.1 serine/threonine-protein kinase MRCK alpha isoform F
NM_001394014.1 NP_001380943.1 serine/threonine-protein kinase MRCK alpha isoform G
NM_003607.4 NP_003598.2 serine/threonine-protein kinase MRCK alpha isoform B
NM_014826.5 NP_055641.3 serine/threonine-protein kinase MRCK alpha isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
9092543 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
11283256 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
9092543 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9418861 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9092543 GOA
Biological Process GO Annotation Evidence References Source
involved in actin cytoskeleton organization IDA
IDA: Inferred from direct assay
9418861 GOA
involved in actomyosin structure organization IMP
IMP: Inferred from mutant phenotype
18854160 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
18854160 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9092543 GOA
Cellular Component GO Annotation Evidence References Source
located in actomyosin IDA
IDA: Inferred from direct assay
18854160 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC42BPA Protein Structure

Pkinase

Pkinase: Protein kinase domain (77 - 343)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (361 - 406)

DMPK_coil

DMPK_coil: DMPK coiled coil domain like (881 - 941)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (1000 - 1050)

CNH

CNH: CNH domain (1220 - 1482)

  • 0
  • 300
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  • 1200
  • 1500
  • 1781 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase MRCK alpha

  • CDC42 binding protein kinase alpha (DMPK-like)

CDC42BPA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDC42BPA Q5VT25 CDC42BPA Homo sapiens Q5VT25
Y2H Fragment Pooling
23414517
Intra
CDC42BPA Q5VT25 CDC42BPA Homo sapiens Q5VT25
Anti Tag CoIP
11283256
Intra
CDC42BPA Q5VT25 CDC42BPA Homo sapiens Q5VT25
Protein Kinase Assay
11283256
Intra
CDC42BPA Q5VT25 CDC42 Homo sapiens P60953
Y2H Pooling
20936779
Intra
CDC42BPA Q5VT25 CDC42 Homo sapiens P60953
IF
9418861
Intra
CDC42BPA Q5VT25 CDC42BPA Homo sapiens Q5VT25
Crosslink
11283256
Intra
CDC42BPA Q5VT25 CDC42 Homo sapiens P60953
Lambda Phage
9418861
Intra
CDC42BPA Q5VT25 CDC42 Homo sapiens P60953
Far-WB
9418861
Cross: Cross-species interaction Intra: Intraspecies interaction

CDC42BPA Antibodies

Cat. No. Product Name Application Reactivity
HY-P810947 MRCK alpha Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Myotonic Dystrophy 1

  • Myotonic Dystrophy

  • Dystrophia Myotonica

  • Steinert Disease

  • Myotonic Dystrophy Type 1

  • Myotonia Atrophica

  • DM1

  • Congenital Myotonic Dystrophy

  • Myotonia Dystrophica

  • Steinert Myotonic Dystrophy

  • Dystrophia Myotonica 1

  • Dm

  • Steinert'S Disease

  • Steinert Myotonic Dystrophy Syndrome

  • Myotonic Dystrophy Of Steinert

  • Dystrophia Myotonica Type 1

  • Myotonic Dystrophy Congenital

  • Dystrophy, Myotonic, Type 1

  • Dm - [Dystrophia Myotonica]

  • Myotonic Muscular Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02301 CDC42BPA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CDC42BPA VGNC VGNC:60657
Macaca mulatta CDC42BPA VGNC VGNC:70799
Rattus norvegicus CDC42BPA RGD RGD:621406
Canis familiaris CDC42BPA VGNC VGNC:38997
Mus musculus CDC42BPA MGD MGI:2441841
Bos taurus CDC42BPA VGNC VGNC:27069
Others CDC42BPA NCBI