Kiss1r - KISS1 receptor Gene

Also Known as Gpr54; KiSS-1; kiSS-1R

Species: Mus musculus

Gene Type: protein coding
Gene ID: 114229

About Kiss1r

Chromosome 10: 79,752,805-79,758,107 forward strand.GRCm39:CM001003.3

This gene has 3 transcripts (splice variants), 135 orthologues, 15 paralogues and is associated with 135 phenotypes. Ubiquitous expression in lung adult (RPKM 3.2), adrenal adult (RPKM 2.2) and 26 other tissues.

Summary

Enables G protein-coupled peptide receptor activity. Acts upstream of or within negative regulation of cell migration; negative regulation of cell population proliferation; and signal transduction. Located in cell surface. Is expressed in alimentary system; brain; genitourinary system; sensory organ; and thymus. Used to study hypogonadotropic hypogonadism 8 with or without anosmia. Human ortholog(s) of this gene implicated in central precocious puberty 1; hypogonadism; and hypogonadotropic hypogonadism 8 with or without anosmia. Orthologous to human KISS1R (KISS1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Kiss1r Products (2)

mRNA Protein Name
NM_053244.5 NP_444474.1 kiSS-1 receptor isoform 1
NM_001359010.1 NP_001345939.1 kiSS-1 receptor isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled peptide receptor activity IDA
IDA: Inferred from direct assay
11414709 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12359743 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of cell migration IPI
IPI: Inferred from physical interaction
12359743 MGI
acts upstream of or within negative regulation of cell population proliferation IPI
IPI: Inferred from physical interaction
12359743 MGI
acts upstream of or within signal transduction IDA
IDA: Inferred from direct assay
11414709 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
12359743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Kiss1r Protein Structure

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (42 - 333)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (43 - 69)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (76 - 102)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (114 - 144)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (156 - 176)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (200 - 229)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (255 - 285)

7tmA_KiSS1R

7tmA_KiSS1R: cd15095 (301 - 326)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
Protein Preferred Names Protein Names

kiSS-1 receptor

  • G-protein coupled receptor 54

  • G-protein coupled receptor OT7T175

  • kisspeptins receptor

  • metastin receptor

  • orphan G protein-coupled receptor 54

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P0076 TAK-448 99.90% Phase 2
HY-P0076A TAK-448 acetate 99.79% Phase 2
HY-P2161 TAK-683 / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10489 Kisspeptin-14 human 99.70% Unkown
HY-P2161B TAK-683 acetate 99.91% Unkown
HY-RS07316 KISS1R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P2161A TAK-683 TFA / Unkown
HY-P2191 KISS1-305 / Unkown
HY-RS07317 Kiss1r Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07318 Kiss1r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kiss1r NCBI NCBI:84634