FMNL2 - formin like 2 Gene

Also Known as FHOD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 114793

About FMNL2

Cytogenetic location: 2q23.3 Genomic coordinates (GRCh38): 2:152,335,174-152,649,826 (from NCBI)

This gene has 4 transcripts (splice variants), 220 orthologues and 18 paralogues. Broad expression in brain (RPKM 47.7), placenta (RPKM 25.7) and 20 other tissues.

Summary

This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. Alternatively spliced transcript variants encoding different isoforms have been described but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

FMNL2 Products (1)

mRNA Protein Name
NM_052905.4 NP_443137.2 formin-like protein 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in cortical actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21834987 GOA
involved in regulation of cell morphogenesis IMP
IMP: Inferred from mutant phenotype
21834987 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FMNL2 Protein Structure

Drf_GBD

Drf_GBD: Diaphanous GTPase-binding Domain (24 - 144)

Drf_GBD

Drf_GBD: Diaphanous GTPase-binding Domain (218 - 275)

Drf_FH3

Drf_FH3: Diaphanous FH3 Domain (278 - 475)

FH2

FH2: Formin Homology 2 Domain (617 - 982)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1092 a.a.
Protein Preferred Names Protein Names

formin-like protein 2

  • formin homology 2 domain containing 2

Related Diseases

Diseases Alias
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Malignant Breast Melanoma

  • Malignant Melanoma Of Breast

  • Breast Melanoma
Cerebral Amyloid Angiopathy, Itm2b-Related, 2

  • Dementia, Familial Danish

  • Fdd

  • Familial Danish Dementia

  • Heredopathia Ophthalmootoencephalica

  • Hooe

  • Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis

  • Adan Amyloidosis

  • Itm2b-Related Cerebral Amyloid Angiopathy 2

  • Itm2b Amyloidosis

  • Familial Cerebral Amyloid Angiopathy

  • Itm2b-Related Amyloidosis

  • Itm2b-Related Cerebral Amyloid Angiopathy

  • Familial Dementia, Danish Type

  • Cerebral Amyloid Angiopathy, Itm2b-Related 2

  • CAA-ITM2B2

  • Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis

  • Dementia, Familial, Danish
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05003 FMNL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21573 Fmnl2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28091 Fmnl2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FMNL2 VGNC VGNC:29047
Rattus norvegicus FMNL2 RGD RGD:1560248
Mus musculus FMNL2 MGD MGI:1918659
Macaca mulatta FMNL2 VGNC VGNC:99362
Felis catus FMNL2 VGNC VGNC:62305
Others FMNL2 NCBI