Gsr - glutathione-disulfide reductase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116686

Summary

Enables several functions, including glutathione binding activity; glutathione-disulfide reductase (NADPH) activity; and nucleotide binding activity. Involved in several processes, including response to iron(III) ion; response to ischemia; and response to vitamin A. Located in cytosol and mitochondrion. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including Parkinsonism; acute kidney failure (multiple); hemorrhagic cystitis; myoglobinuria; and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase). [provided by Alliance of Genome Resources, Apr 2022]

Gsr Products (1)

mRNA Protein Name
NM_053906.2 NP_446358.2 glutathione reductase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables NADP binding IDA
IDA: Inferred from direct assay
237922 RGD
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
237922 RGD
enables glutathione binding IDA
IDA: Inferred from direct assay
237922 RGD
enables glutathione-disulfide reductase (NADPH) activity IDA
IDA: Inferred from direct assay
237922 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
237922 RGD
Biological Process GO Annotation Evidence References Source
involved in glutathione metabolic process IDA
IDA: Inferred from direct assay
237922 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
21621560 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
24758558 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23905773 RGD
involved in response to iron(III) ion IEP
IEP: Inferred from expression pattern
24388910 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
9434704 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
22894698 RGD
involved in response to oxidative stress IEP
IEP: Inferred from expression pattern
21704983 RGD
involved in response to vitamin A IEP
IEP: Inferred from expression pattern
22984325 RGD
involved in spermatogenesis IMP
IMP: Inferred from mutant phenotype
11874473 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutathione reductase

  • GR

  • GRase

  • glutathione reductase, mitochondrial

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147328 LCS3 Inducer 99.43% Unkown
HY-N7653 Azaleatin 98.86% Unkown
HY-RS05870 GSR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18327 Gsr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24806 Gsr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gsr NCBI NCBI:2936