GSR - glutathione-disulfide reductase Gene
Also Known as GR; GSRD; HEL-75; HEL-S-122m
Species: Homo sapiens
About GSR
This gene has 8 transcripts (splice variants), 201 orthologues, 7 paralogues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 26.7), kidney (RPKM 25.9) and 25 other tissues.
Summary
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
GSR Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_000637.5 | NP_000628.2 | glutathione reductase, mitochondrial isoform 1 precursor |
| NM_001195102.3 | NP_001182031.1 | glutathione reductase, mitochondrial isoform 2 |
| NM_001195103.3 | NP_001182032.1 | glutathione reductase, mitochondrial isoform 3 |
| NM_001195104.3 | NP_001182033.1 | glutathione reductase, mitochondrial isoform 4 |
GSR Protein Structure
Pyr_redox_2: Pyridine nucleotide-disulphide oxidoreductase (66 - 378)
Pyr_redox: Pyridine nucleotide-disulphide oxidoreductase (234 - 304)
Pyr_redox_dim: Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain (411 - 521)
- 0
- 100
- 200
- 300
- 400
- 522 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
glutathione reductase, mitochondrial |
|
GSR Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80693 | Glutathione Reductase Antibody (YA403) | WB | Human, Mouse |
| HY-P80693A | Glutathione Reductase Antibody (YA403)(PBS only) | WB | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Hemolytic Anemia Due To Glutathione Reductase Deficiency |
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| Riboflavin Deficiency |
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| Senile Cataract |
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| Chagas Disease |
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| Pyridoxine Deficiency |
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| Diabetic Cataract |
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| Limbic Encephalitis |
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| Hemolytic Anemia |
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| Sleeping Sickness |
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| Methemoglobinemia |
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| Cutaneous Leishmaniasis |
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| Glutamate-Cysteine Ligase Deficiency |
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| Hemorrhage, Intracerebral |
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| Wilson Disease |
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| Iron Deficiency Anemia |
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| Beta-Thalassemia |
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| Malaria |
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| Cardiac Arrest |
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| Lipomatosis |
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| Trimethoprim Allergy |
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| Cataract |
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| Rett Syndrome |
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| Heart Disease |
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| Friedreich Ataxia |
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| Reye Syndrome |
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| Cerebral Palsy |
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| Huntington Disease |
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| Parkinson Disease 17 |
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| Epilepsy |
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| Multiple Sclerosis |
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| Myocardial Infarction |
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| Microcephaly And Chorioretinopathy 2 |
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| Glucosephosphate Dehydrogenase Deficiency |
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| Developmental And Epileptic Encephalopathy 75 |
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| Asthma |
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| Amyotrophic Lateral Sclerosis 1 |
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| Osteoporosis |
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| Diabetes Mellitus |
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| Hypertension, Essential |
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| Alcohol Dependence |
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| Stroke, Ischemic |
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| Alzheimer Disease, Familial, 1 |
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| Parkinson Disease, Late-Onset |
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| Type 2 Diabetes Mellitus |
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| Nervous System Disease |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | GSR | VGNC | VGNC:110510 |
| Rattus norvegicus | GSR | RGD | RGD:621747 |
| Macaca mulatta | GSR | VGNC | VGNC:84003 |
| Bos taurus | GSR | VGNC | VGNC:29682 |
| Felis catus | GSR | VGNC | VGNC:67488 |
| Mus musculus | GSR | MGD | MGI:95804 |
| Others | GSR | NCBI |