2. Gene
  3. Ap2a1 - adaptor-related protein complex 2, alpha 1 subunit Gene

Ap2a1 - adaptor-related protein complex 2, alpha 1 subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Adtaa

Gene ID: 11771 | Gene type: protein coding

About Ap2a1

Summary

Enables protein kinase binding activity. Involved in clathrin-dependent endocytosis. Located in filopodium tip. Part of AP-2 adaptor complex. Is expressed in brain; cranial ganglion; dorsal root ganglion; and liver. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Ap2a1 Products(2)

mRNA Protein Name
NM_001077264.1 NP_001070732.1 AP-2 complex subunit alpha-1 isoform b
NM_007458.2 NP_031484.1 AP-2 complex subunit alpha-1 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
14555962 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21307259 MGI
Biological Process GO Annotation Evidence Reference Source
involved in clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
23676497 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
35014951 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
35014951 MGI
Cellular Component GO Annotation Evidence Reference Source
part of AP-2 adaptor complex IDA
IDA: Inferred from direct assay
23676497 MGI
located in filopodium tip IDA
IDA: Inferred from direct assay
24305805 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
32341099 MGI
part of membrane coat IDA
IDA: Inferred from direct assay
11879655 MGI
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
32341099 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AP-2 complex subunit alpha-1

100 kDa coated vesicle protein A

adapter-related protein complex 2 alpha-1 subunit

adapter-related protein complex 2 subunit alpha-1

adaptor protein complex AP-2 subunit alpha-1

adaptor protein complex AP-2, alpha 1 subunit

adaptor-related protein co

Ap2a1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Ap2a1 P17426 Grin2b Mus musculus Q01097
Anti Bait CoIP
16710293
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N14035 Garcinia cambogia extract Activator / Unkown
HY-161261 SARS-CoV-2-IN-81 Inhibitor / Unkown
HY-169405 AAK1/HDACs-IN-1 Inhibitor / Unkown
HY-RS00784 AP2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00786 AP2B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00787 AP2M1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00788 AP2S1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22390 Ap2m1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ap2a1 NCBI NCBI:160