UBE2J2 - ubiquitin conjugating enzyme E2 J2 Gene

Also Known as UBC6; NCUBE2; NCUBE-2; PRO2121

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 118424

About UBE2J2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,253,912-1,273,854 (from NCBI)

This gene has 20 transcripts (splice variants), 208 orthologues and 24 paralogues. Broad expression in testis (RPKM 15.7), fat (RPKM 6.0) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

UBE2J2 Products (4)

mRNA Protein Name
NM_058167.3 NP_477515.2 ubiquitin-conjugating enzyme E2 J2 isoform 2
NM_194315.2 NP_919296.1 ubiquitin-conjugating enzyme E2 J2 isoform 1
NM_194457.2 NP_919439.1 ubiquitin-conjugating enzyme E2 J2 isoform 3
NM_194458.2 NP_919440.1 ubiquitin-conjugating enzyme E2 J2 isoform 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: Inferred from direct assay
20061386 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
24019521 GOA
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
24807418 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
36528027 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
24807418 GOA
Cellular Component GO Annotation Evidence References Source
part of ubiquitin ligase complex IPI
IPI: Inferred from physical interaction
24807418 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2J2 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (16 - 129)

  • 0
  • 100
  • 200
  • 259 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 J2

  • E2 ubiquitin-conjugating enzyme J2

UBE2J2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBE2J2 Q8N2K1 TRIM59 Homo sapiens Q8IWR1
Y2H Array
32296183
Intra
UBE2J2 Q8N2K1 TRIM59 Homo sapiens Q8IWR1
Y2H Prey Pooling
32296183
Intra
UBE2J2 Q8N2K1 ELOVL7 Homo sapiens A1L3X0
Y2H Prey Pooling
32296183
Intra
UBE2J2 Q8N2K1 ELOVL7 Homo sapiens A1L3X0
Y2H Array
32296183
Intra
UBE2J2 Q8N2K1 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
UBE2J2 Q8N2K1 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
UBE2J2 Q8N2K1 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
UBE2J2 Q8N2K1 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
UBE2J2 Q8N2K1 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2J2 Proteins

Cat. No. Product Name Accession Purity
HY-P71404 UBE2J2 Protein, Human (GST) Q8N2K1-1 (E124-R224) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15351 UBE2J2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19535 Ube2j2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26031 Ube2j2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBE2J2 VGNC VGNC:79189
Bos taurus UBE2J2 VGNC VGNC:36586
Rattus norvegicus UBE2J2 RGD RGD:1359523
Mus musculus UBE2J2 MGD MGI:2153608
Canis familiaris UBE2J2 VGNC VGNC:48056
Felis catus UBE2J2 VGNC VGNC:107687
Others UBE2J2 NCBI