Cldn3 - claudin 3 Gene

Also Known as mRVP1; Cpetr2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12739

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a low-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein is highly overexpressed in uterine carcinosarcoma. This protein is also predominantly present in brain endothelial cells, where it plays a specific role in the establishment and maintenance of blood brain barrier tight junction morphology. [provided by RefSeq, Aug 2012]

Cldn3 Products (1)

mRNA Protein Name
NM_009902.4 NP_034032.1 claudin-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10562289 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10562289 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
IDA: Inferred from direct assay
10508613 MGI
involved in cell junction maintenance IMP
IMP: Inferred from mutant phenotype
12734665 MGI
involved in epithelial cell morphogenesis IDA
IDA: Inferred from direct assay
22696678 MGI
involved in establishment of endothelial blood-brain barrier IMP
IMP: Inferred from mutant phenotype
12734665 MGI
Cellular Component GO Annotation Evidence References Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
9892664 MGI
located in bicellular tight junction IDA
IDA: Inferred from direct assay
9892664 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
12734665 MGI
located in lateral plasma membrane IDA
IDA: Inferred from direct assay
22275141 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
24588076 MGI
located in tight junction IDA
IDA: Inferred from direct assay
24588076 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-3

  • CPE-R 2

  • CPE-receptor 2

  • clostridium perfringens enterotoxin receptor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02771 CLDN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20885 Cldn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27402 Cldn3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991946 Anti-CLDN3 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn3 NCBI NCBI:1365