Drosha - drosha, ribonuclease type III Gene

Mus musculus

Also known as Rn3; Etohi2; Rnasen; 1110013A17Rik

Gene ID: 14000 | Gene type: protein coding

About Drosha

Summary

Enables endoribonuclease activity and primary miRNA binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including ncRNA metabolic process; regulation of miRNA metabolic process; and regulation of regulatory T cell differentiation. Located in postsynaptic density. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; hemolymphoid system gland; and tooth. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]

Drosha Products(2)

mRNA	Protein	Name
NM_001130149.1	NP_001123621.1	ribonuclease 3
NM_026799.3	NP_081075.3	ribonuclease 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	20424607	MGI
enables primary miRNA binding	IDA IDA: Inferred from direct assay	28819115	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19632182	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	20424607	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22053081	MGI
acts upstream of or within pre-miRNA processing	IDA IDA: Inferred from direct assay	18604195	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22000014	MGI
acts upstream of or within regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18725527	MGI
acts upstream of or within regulation of miRNA metabolic process	IMP IMP: Inferred from mutant phenotype	22053081	MGI
acts upstream of or within regulation of regulatory T cell differentiation	IMP IMP: Inferred from mutant phenotype	18725527	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22897173	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	22897173	MGI
is active in postsynaptic density	IDA IDA: Inferred from direct assay	22897173	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	22897173	MGI
is active in postsynaptic density	IEP IEP: Inferred from expression pattern	22897173	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ribonuclease 3

RNase III	ethanol induced 2
protein Drosha	ribonuclease III, nuclear

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17624	Framycetin	Inhibitor	/	Unkown
HY-17624A	Framycetin sulfate	Inhibitor	98.0%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132598A	Miravirsen sodium		99.44%	Phase 2
HY-132598	Miravirsen	Inhibitor	97.37%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15843	MIR96-IN-1		99.57%	Unkown
HY-RS04012	DROSHA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-17624S	Framycetin-d2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Drosha	NCBI	NCBI:29102

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