Drosha - drosha, ribonuclease type III Gene

Also Known as Rn3; Etohi2; Rnasen; 1110013A17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14000

Summary

Enables endoribonuclease activity and primary miRNA binding activity. Involved in positive regulation of gene expression. Acts upstream of or within several processes, including ncRNA metabolic process; regulation of miRNA metabolic process; and regulation of regulatory T cell differentiation. Located in postsynaptic density. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; hemolymphoid system gland; and tooth. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]

Drosha Products (2)

mRNA Protein Name
NM_001130149.1 NP_001123621.1 ribonuclease 3
NM_026799.3 NP_081075.3 ribonuclease 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA endonuclease activity IDA
IDA: Inferred from direct assay
20424607 MGI
enables primary miRNA binding IDA
IDA: Inferred from direct assay
28819115 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19632182 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within miRNA metabolic process IMP
IMP: Inferred from mutant phenotype
20424607 MGI
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22053081 MGI
acts upstream of or within pre-miRNA processing IDA
IDA: Inferred from direct assay
18604195 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
22000014 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
18725527 MGI
acts upstream of or within regulation of miRNA metabolic process IMP
IMP: Inferred from mutant phenotype
22053081 MGI
acts upstream of or within regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
18725527 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22897173 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
22897173 MGI
is active in postsynaptic density IDA
IDA: Inferred from direct assay
22897173 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
22897173 MGI
is active in postsynaptic density IEP
IEP: Inferred from expression pattern
22897173 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ribonuclease 3

  • RNase III

  • ethanol induced 2

  • protein Drosha

  • ribonuclease III, nuclear

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17624 Framycetin Inhibitor / Unkown
HY-17624A Framycetin sulfate Inhibitor 98.0% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-132598A Miravirsen sodium 99.44% Phase 2
HY-132598 Miravirsen Inhibitor 97.37% Phase 2

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15843 MIR96-IN-1 99.57% Unkown
HY-RS04012 DROSHA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-17624S Framycetin-d2 / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Drosha NCBI NCBI:29102