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SELENOM - selenoprotein M Gene

Also Known as SELM; SEPM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 140606

About SELENOM

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:31,104,777-31,107,568 (from NCBI)

This gene has 9 transcripts (splice variants), 186 orthologues and 1 paralogue. Ubiquitous expression in prostate (RPKM 54.6), endometrium (RPKM 49.8) and 23 other tissues.

Summary

The protein encoded by this gene belongs to the selenoprotein M/SEP15 family. The exact function of this protein is not known. It is localized in the perinuclear region, is highly expressed in the brain, and may be involved in neurodegenerative disorders. Transgenic mice with targeted deletion of this gene exhibit increased weight gain, suggesting a role for this gene in the regulation of body weight and energy metabolism. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Dec 2016]

SELENOM Products (1)

mRNA	Protein	Name
NM_080430.4	NP_536355.1	selenoprotein M precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SELENOM Protein Structure

Sep15_SelM

0
100
145 a.a.

Protein Preferred Names	Protein Names
selenoprotein M	selenoprotein SelM

SELENOM Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SELENOM	Q8WWX9	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	SELENOM	Q8WWX9	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	SELENOM	Q8WWX9	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	SELENOM	Q8WWX9	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	SELENOM	Q8WWX9	NIPA1	Homo sapiens	Q7RTP0	Y2H Array	32296183
Intra	SELENOM	Q8WWX9	NIPA1	Homo sapiens	Q7RTP0	Y2H Prey Pooling	32296183
Intra	SELENOM	Q8WWX9	SEC11C	Homo sapiens	Q9BY50	Y2H Prey Pooling	32296183
Intra	SELENOM	Q8WWX9	SEC11C	Homo sapiens	Q9BY50	Validated Y2H	32296183
Intra	SELENOM	Q8WWX9	SEC11C	Homo sapiens	Q9BY50	Y2H Array	32296183
Intra	SELENOM	Q8WWX9	HSPE1	Homo sapiens	P61604	Y2H Array	32296183
Intra	SELENOM	Q8WWX9	HSPE1	Homo sapiens	P61604	Y2H Prey Pooling	32296183
Intra	SELENOM	Q8WWX9	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	SELENOM	Q8WWX9	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	SELENOM	Q8WWX9	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	SELENOM	Q8WWX9	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	SELENOM	Q8WWX9	SGTB	Homo sapiens	Q96EQ0	Y2H Prey Pooling	32296183
Intra	SELENOM	Q8WWX9	SGTB	Homo sapiens	Q96EQ0	Validated Y2H	32296183
Intra	SELENOM	Q8WWX9	SGTB	Homo sapiens	Q96EQ0	Y2H Array	32296183
Intra	SELENOM	Q8WWX9	REEP4	Homo sapiens	Q9H6H4	Y2H Array	32296183
Intra	SELENOM	Q8WWX9	REEP4	Homo sapiens	Q9H6H4	Y2H Prey Pooling	32296183
Intra	SELENOM	Q8WWX9	REEP4	Homo sapiens	Q9H6H4	Validated Y2H	32296183
Intra	SELENOM	Q8WWX9	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	SELENOM	Q8WWX9	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SELENOM Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71603	SELM Protein, Human	Q8WWX9 (A24-L145, U48S)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Keshan Disease	Caused By Deficiency Of Selenium In The Diet Enlarged Heart And Poor Heart Function
Cataract 8, Multiple Types	Ccv Cataract, Congenital, Volkmann Type CTRCT8 Cataract 8 Multiple Types Cataract Congenital Volkmann Type Cutaneous Collagenous Vasculopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12638	SELENOM Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20642	Selenom Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27152	Selenom Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SELENOM	VGNC	VGNC:82552
Bos taurus	SELENOM	VGNC	VGNC:53920
Rattus norvegicus	SELENOM	RGD	RGD:1565037
Mus musculus	SELENOM	MGD	MGI:2149786
Others	SELENOM	NCBI