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LRFN5 - leucine rich repeat and fibronectin type III domain containing 5 Gene

Also Known as SALM5; FIGLER8; C14orf146

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 145581

About LRFN5

Cytogenetic location: 14q21.1 Genomic coordinates (GRCh38): 14:41,606,876-41,904,549 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 25 paralogues. Biased expression in brain (RPKM 2.4), adrenal (RPKM 0.8) and 13 other tissues.

Summary

This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [provided by RefSeq, Sep 2016]

LRFN5 Products (4)

mRNA	Protein	Name
NM_001330106.2	NP_001317035.1	leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 2 precursor
NM_001346173.2	NP_001333102.1	leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 1 precursor
NM_001346175.2	NP_001333104.1	leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 2 precursor
NM_152447.5	NP_689660.2	leucine-rich repeat and fibronectin type-III domain-containing protein 5 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	27152329	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	27152329	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRFN5 Protein Structure

LRR_5

I-set

0
200
400
600
719 a.a.

Protein Preferred Names	Protein Names
leucine-rich repeat and fibronectin type-III domain-containing protein 5	fibronectin type III, immunoglobulin and leucine rich repeat domains 8

Related Diseases

Diseases	Alias
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07783	LRFN5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21633	Lrfn5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28151	Lrfn5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LRFN5	VGNC	VGNC:42764
Macaca mulatta	LRFN5	VGNC	VGNC:74318
Mus musculus	LRFN5	MGD	MGI:2144814
Bos taurus	LRFN5	VGNC	VGNC:30979
Rattus norvegicus	LRFN5	RGD	RGD:1309357
Felis catus	LRFN5	VGNC	VGNC:63278
Others	LRFN5	NCBI