Gfi1b - growth factor independent 1B Gene

Also Known as Gfi-1B

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14582

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in regulation of histone methylation and regulation of myeloid cell differentiation. Predicted to be located in nuclear matrix; nucleoplasm; and plasma membrane. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in eye; gut; immune system; liver; and testis. Human ortholog(s) of this gene implicated in gray platelet syndrome and platelet-type bleeding disorder 17. Orthologous to human GFI1B (growth factor independent 1B transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]

Gfi1b Products (2)

mRNA Protein Name
NM_001160406.1 NP_001153878.1 zinc finger protein Gfi-1b isoform 2
NM_008114.3 NP_032140.1 zinc finger protein Gfi-1b isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16688220 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of granulocyte differentiation IDA
IDA: Inferred from direct assay
17707228 MGI
involved in regulation of erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
17707228 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein Gfi-1b

  • growth factor independent protein 1B

Gfi1b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gfi1b O70237 Suv39h1 Mus musculus O54864
Anti Bait CoIP
16688220
Intra
Gfi1b O70237 Ehmt2 Mus musculus Q9Z148
Anti Bait CoIP
16688220
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-183105 DC551040 / Unkown
HY-183202 NCD38 / Unkown
HY-RS05379 GFI1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gfi1b NCBI NCBI:8328