Ehmt2 - euchromatic histone lysine N-methyltransferase 2 Gene

Also Known as G9a; Bat8; NG36; KMT1C; D17Ertd710e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 110147

About Ehmt2

Chromosome 17: 35,117,445-35,133,028 forward strand.GRCm39:CM001010.3

This gene has 14 transcripts (splice variants), 210 orthologues, 20 paralogues and is associated with 22 phenotypes. Ubiquitous expression in ovary adult (RPKM 86.7), testis adult (RPKM 83.8) and 28 other tissues.

Summary

Enables several functions, including C2H2 zinc finger domain binding activity; histone-lysine N-methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation; histone methylation; and regulation of DNA replication. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of autophagosome assembly; and response to cocaine. Located in nucleus. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt2 Products (7)

mRNA Protein Name
NM_001286573.2 NP_001273502.1 histone-lysine N-methyltransferase EHMT2 isoform c
NM_147151.3 NP_671493.1 histone-lysine N-methyltransferase EHMT2 isoform b
NM_001403867.1 NP_001390796.1 histone-lysine N-methyltransferase EHMT2 isoform e
NM_145830.3 NP_665829.1 histone-lysine N-methyltransferase EHMT2 isoform a
NM_001403870.1 NP_001390799.1 histone-lysine N-methyltransferase EHMT2 isoform g
NM_001286575.2 NP_001273504.1 histone-lysine N-methyltransferase EHMT2 isoform d
NM_001403869.1 NP_001390798.1 histone-lysine N-methyltransferase EHMT2 isoform f

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables C2H2 zinc finger domain binding IPI
IPI: Inferred from physical interaction
16702210 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21402781 MGI
enables histone H3K27 methyltransferase activity IDA
IDA: Inferred from direct assay
15774718 MGI
enables histone H3K27 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
17212651 MGI
enables histone H3K56 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
22387026 MGI
enables histone H3K9 methyltransferase activity EXP
EXP: Inferred from Experiment
17707230 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: Inferred from direct assay
15774718 MGI
enables histone H3K9 methyltransferase activity IMP
IMP: Inferred from mutant phenotype
15788566 MGI
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
22770845 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15774718 MGI
enables protein-lysine N-methyltransferase activity IDA
IDA: Inferred from direct assay
19144645 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA methylation-dependent heterochromatin formation IDA
IDA: Inferred from direct assay
18818694 MGI
acts upstream of or within behavioral response to cocaine IMP
IMP: Inferred from mutant phenotype
24584053 MGI
acts upstream of or within cellular response to cocaine IDA
IDA: Inferred from direct assay
24584053 MGI
acts upstream of or within fertilization IMP
IMP: Inferred from mutant phenotype
17599069 MGI
acts upstream of or within negative regulation of autophagosome assembly IMP
IMP: Inferred from mutant phenotype
23918802 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: Inferred from mutant phenotype
17212651 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17392792 MGI
acts upstream of or within neuron fate specification IMP
IMP: Inferred from mutant phenotype
24584053 MGI
acts upstream of or within oocyte development IMP
IMP: Inferred from mutant phenotype
17599069 MGI
acts upstream of or within organ growth IMP
IMP: Inferred from mutant phenotype
17599069 MGI
acts upstream of or within phenotypic switching IMP
IMP: Inferred from mutant phenotype
24584053 MGI
acts upstream of or within protein methylation IMP
IMP: Inferred from mutant phenotype
17599069 MGI
involved in regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
22387026 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17599069 MGI
acts upstream of or within spermatid development IMP
IMP: Inferred from mutant phenotype
17599069 MGI
acts upstream of or within synaptonemal complex assembly IMP
IMP: Inferred from mutant phenotype
17599069 MGI
Cellular Component GO Annotation Evidence References Source
NOT located in nucleolus IDA
IDA: Inferred from direct assay
16702210 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15493016 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ehmt2 Protein Structure

PHA03247

PHA03247: cl33720 (4 - 257)

EHMT_ZBD

EHMT_ZBD: cd20905 (472 - 601)

ANKYR

ANKYR: COG0666 (681 - 873)

ANK

ANK: sd00045 (738 - 767)

Ank_2

Ank_2: pfam12796 (774 - 867)

ANK

ANK: sd00045 (802 - 834)

ANK

ANK: sd00045 (837 - 867)

Ank_2

Ank_2: pfam12796 (841 - 933)

ANK

ANK: sd00045 (869 - 900)

ANK

ANK: sd00045 (902 - 933)

SET_EHMT2

SET_EHMT2: cd10533 (1000 - 1238)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1263 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EHMT2

  • H3-K9-HMTase 3

  • HLA-B associated transcript 8

  • histone H3-K9 methyltransferase 3

  • histone-lysine N-methyltransferase, H3 lysine-9 specific 3

  • protein G9a

Ehmt2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ehmt2 Q9Z148 Hoxa9 Mus musculus P09631
Anti Tag CoIP
24532712
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-16705 BRD4770 Inhibitor 99.79% Unkown
HY-111778 EHMT2-IN-1 Inhibitor 99.85% Unkown
HY-161759 MS152 Inhibitor 99.36% Unkown
HY-111904 EHMT2-IN-2 Inhibitor 99.0% Unkown
HY-183058 EZM8266 Inhibitor 98.24% Unkown
HY-15647 BRD9539 Inhibitor 99.73% Unkown
HY-44062 G9a-IN-1 Inhibitor 98.12% Unkown
HY-133031 CSV0C018875 Inhibitor / Unkown
HY-133031A CSV0C018875 hydrochloride Inhibitor / Unkown
HY-183602 FRC-303 Inhibitor / Unkown
HY-183603 FRC-222 Inhibitor / Unkown
HY-RS04230 EHMT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04231 Ehmt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04232 Ehmt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ehmt2 NCBI NCBI:10919