2. Gene
  3. Ehmt2 - euchromatic histone lysine N-methyltransferase 2 Gene

Ehmt2 - euchromatic histone lysine N-methyltransferase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as G9a; Bat8; NG36; KMT1C; D17Ertd710e

Gene ID: 110147 | Gene type: protein coding

About Ehmt2

Chromosome 17: 35,117,445-35,133,028 forward strand.GRCm39:CM001010.3

This gene has 14 transcripts (splice variants), 210 orthologues, 20 paralogues and is associated with 22 phenotypes. Ubiquitous expression in ovary adult (RPKM 86.7), testis adult (RPKM 83.8) and 28 other tissues.

Summary

Enables several functions, including C2H2 zinc finger domain binding activity; histone-lysine N-methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation; histone methylation; and regulation of DNA replication. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of autophagosome assembly; and response to cocaine. Located in nucleus. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt2 Products(7)

mRNA Protein Name
NM_001286573.2 NP_001273502.1 histone-lysine N-methyltransferase EHMT2 isoform c
NM_147151.3 NP_671493.1 histone-lysine N-methyltransferase EHMT2 isoform b
NM_001403867.1 NP_001390796.1 histone-lysine N-methyltransferase EHMT2 isoform e
NM_145830.3 NP_665829.1 histone-lysine N-methyltransferase EHMT2 isoform a
NM_001403870.1 NP_001390799.1 histone-lysine N-methyltransferase EHMT2 isoform g
NM_001286575.2 NP_001273504.1 histone-lysine N-methyltransferase EHMT2 isoform d
NM_001403869.1 NP_001390798.1 histone-lysine N-methyltransferase EHMT2 isoform f

Ehmt2 Protein Structure

PHA03247

PHA03247: cl33720 (4 - 257)

EHMT_ZBD

EHMT_ZBD: cd20905 (472 - 601)

ANKYR

ANKYR: COG0666 (681 - 873)

ANK

ANK: sd00045 (738 - 767)

Ank_2

Ank_2: pfam12796 (774 - 867)

ANK

ANK: sd00045 (802 - 834)

ANK

ANK: sd00045 (837 - 867)

Ank_2

Ank_2: pfam12796 (841 - 933)

ANK

ANK: sd00045 (869 - 900)

ANK

ANK: sd00045 (902 - 933)

SET_EHMT2

SET_EHMT2: cd10533 (1000 - 1238)

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  • 1263 a.a.
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase EHMT2

H3-K9-HMTase 3

HLA-B associated transcript 8

histone H3-K9 methyltransferase 3

histone-lysine N-methyltransferase, H3 lysine-9 specific 3

protein G9a

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16705 BRD4770 Inhibitor 99.69% Unkown
HY-15647 BRD9539 Inhibitor 99.74% Unkown
HY-111904 EHMT2-IN-2 Inhibitor ≥99.0% Unkown
HY-111778 EHMT2-IN-1 Inhibitor 99.85% Unkown
HY-133031 CSV0C018875 Inhibitor / Unkown
HY-44062 G9a-IN-1 Inhibitor 98.12% Unkown
HY-RS04230 EHMT2 Human Pre-designed siRNA Set A / Unkown
HY-RS04231 Ehmt2 Mouse Pre-designed siRNA Set A / Unkown
HY-RS04232 Ehmt2 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ehmt2 NCBI NCBI:10919