Suv39h1 - suppressor of variegation 3-9 1 Gene

Also Known as mIS6; KMT1A; DXHXS7466e; H3-K9-HMTase 1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20937

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and Histone Methyltransferase activity (H3-K9 specific). Involved in histone H3-K9 methylation; negative regulation of circadian rhythm; and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including blastocyst hatching; positive regulation of histone H3-K9 trimethylation; and regulation of cellular response to stress. Located in heterochromatin and nucleus. Part of chromatin silencing complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Suv39h1 Products (3)

mRNA	Protein	Name
NM_001290716.3	NP_001277645.1	histone-lysine N-methyltransferase SUV39H1 isoform 2
NM_001358237.2	NP_001345166.1	histone-lysine N-methyltransferase SUV39H1 isoform 3
NM_011514.3	NP_035644.1	histone-lysine N-methyltransferase SUV39H1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21402781	MGI
enables histone H3K9 methyltransferase activity	IDA IDA: Inferred from direct assay	10949293	MGI
enables histone H3K9 methyltransferase activity	IGI IGI: Inferred from genetic interaction	15788566	MGI
enables histone H3K9 methyltransferase activity	IMP IMP: Inferred from mutant phenotype	23695662	MGI
enables histone H3K9me2 methyltransferase activity	IGI IGI: Inferred from genetic interaction	23451023	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16688220	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	24413057	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within blastocyst hatching	IMP IMP: Inferred from mutant phenotype	27869233	MGI
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	24413057	MGI
acts upstream of or within determination of adult lifespan	IGI IGI: Inferred from genetic interaction	23695662	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24413057	MGI
involved in negative regulation of gene expression, epigenetic	IMP IMP: Inferred from mutant phenotype	24413057	MGI
acts upstream of or within regulation of DNA repair	IMP IMP: Inferred from mutant phenotype	23695662	MGI
acts upstream of or within regulation of bone mineralization	IGI IGI: Inferred from genetic interaction	23695662	MGI
acts upstream of or within regulation of cellular senescence	IMP IMP: Inferred from mutant phenotype	23695662	MGI
acts upstream of or within regulation of multicellular organism growth	IGI IGI: Inferred from genetic interaction	23695662	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	11788710	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	18004385	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18004385	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
histone-lysine N-methyltransferase SUV39H1	Suv39h histone methyltransferase histone H3-K9 methyltransferase 1 position-effect variegation 3-9 homolog su(var)3-9 homolog 1 suppressor of variegation 3-9 homolog 1

Suv39h1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Suv39h1	O54864	Myod1	Mus musculus	P10085	Anti Bait CoIP	16858404
Intra	Suv39h1	O54864	Myod1	Mus musculus	P10085	Pull Down	16858404

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150190	F5446		99.73%	Unkown
HY-15647	BRD9539	Inhibitor	99.73%	Unkown
HY-133567	SET7-IN-DC21	Inhibitor	/	Unkown
HY-13689G	Go 6983 (GMP)		/	Unkown
HY-RS14051	SUV39H1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185849	SETDB1-IN-1	Inhibitor	/	Unkown
HY-RS17179	Suv39h1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23629	Suv39h1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Suv39h1	NCBI	NCBI:6839